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Proxy records generated from chemical composition and radiocarbon dating of a sediment sequence collected from the El Potosi Basin provide information about variable hydroclimate of the subtropical northeastern Mexico since the last glacial maximum (LGM). Minimal amounts of runoff and more carbonate deposition during >19 ka represent the LGM. The deglaciation was wetter compared to the LGM and enhanced runoff during similar to 19-12 ka transported more Ti-bearing clastics from a relatively humid watershed. Over the deglaciation, the basin received more runoff during the Bolling-Allerod compared to the Heinrich Stadial 1 and Younger Dryas. Reduction in the amount of runoff during similar to 10-1 ka and deposition of unweathered Si-bearing clastics during similar to 4-1 ka suggest that the Holocene was drier compared to the deglaciation. Hydroclimates of the northeastern Mexico and southern US were synchronous during the LGM as well as deglaciation. Change from the drier LGM to wetter Bolling-Allerod occurred as the Gulf of Mexico became warmer and the region received more summer precipitation. However, the dissimilarities observed in regional hydroclimates of the Holocene need further evaluation. (C) 2015 Elsevier BY. All rights reserved.