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DOI10.2174/1566524016666160225153659
cAMP-Response Element-Binding 3-Like Protein 1 (CREB3L1) is Required for Decidualization and its Expression is Decreased in Women with Endometriosis
Ahn, J. I.1,2; Yoo, J. -Y.3; Kim, T. H.3; Kim, Y. I.1,2; Ferguson, S. D.3; Fazleabas, A. T.3,4; Young, S. L.5; Lessey, B. A.6; Ahn, J. Y.2; Lim, J. M.1,2; Jeong, J. -W.3,4
通讯作者Lim, J. M. ; Jeong, J. -W.
来源期刊CURRENT MOLECULAR MEDICINE
ISSN1566-5240
EISSN1875-5666
出版年2016
卷号16期号:3页码:276-287
英文摘要

Endometriosis is a major cause of infertility and pelvic pain, affecting more than 10% of reproductive-aged women. Progesterone resistance has been observed in the endometrium of women with this disease, as evidenced by alterations in progesterone-responsive gene and protein expression. cAMP-Response Element-Binding 3-like protein 1 (Creb3l1) has previously been identified as a progesterone receptor (PR) target gene in mouse uterus via high density DNA microarray analysis. However, CREB3L1 function has not been studied in the context of endometriosis and uterine biology. In this study, we validated progesterone (P4) regulation of Creb3l1 in the uteri of wild-type and progesterone receptor knockout (PRKO) mice. Furthermore, we observed that CREB3L1 expression was significantly higher in secretory phase human endometrium compared to proliferative phase and that CREB3L1 expression was significantly decreased in the endometrium of women with endometriosis. Lastly, by transfecting CREB3L1 siRNA into cultured human endometrial stromal cells (hESCs) prior to hormonal induction of in vitro decidualization, we showed that CREB3L1 is required for the decidualization process. Interestingly, phosphorylation of ERK1/2, critical factor for decidualization, was also significantly reduced in CREB3L1-silenced hESCs. It is known that hESCs from patients with endometriosis show impaired decidualization and that dysregulation of the P4-PR signaling axis is linked to a variety of endometrial diseases including infertility and endometriosis. Therefore, these results suggest that CREB3L1 is required for decidualization in mice and humans and may be linked to the pathogenesis of endometriosis in a P4-dependent manner.


英文关键词CREB3L1 decidualization endometrium endometriosis progesterone uterus
类型Article
语种英语
国家South Korea ; USA
收录类别SCI-E
WOS记录号WOS:000372550400007
WOS关键词PROGESTERONE-RECEPTOR-A ; STRESS TRANSDUCER OASIS ; STROMAL CELLS ; GENE-EXPRESSION ; SIGNAL TRANSDUCER ; CREB/ATF-FAMILY ; MAP KINASE ; IMPLANTATION ; ACTIVATOR ; BETA
WOS类目Medicine, Research & Experimental
WOS研究方向Research & Experimental Medicine
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/192214
作者单位1.Seoul Natl Univ, Lab Stem Cell & Bioevaluat, Biomodulat, Seoul 151921, South Korea;
2.Seoul Natl Univ, Dept Agr Biotechnol, Seoul 151921, South Korea;
3.Michigan State Univ, Dept Obstet Gynecol & Reprod Biol, Coll Human Med, 333 Bostwick Ave NE,Suite 4024, Grand Rapids, MI 49503 USA;
4.Spectrum Hlth Syst, Dept Womens Hlth, Grand Rapids, MI 49341 USA;
5.Univ N Carolina, Dept Obstet & Gynecol, Chapel Hill, NC 27599 USA;
6.Greenville Hosp Syst, Univ Med Grp, Dept Obstet & Gynecol, Greenville, SC 29605 USA
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GB/T 7714
Ahn, J. I.,Yoo, J. -Y.,Kim, T. H.,et al. cAMP-Response Element-Binding 3-Like Protein 1 (CREB3L1) is Required for Decidualization and its Expression is Decreased in Women with Endometriosis[J],2016,16(3):276-287.
APA Ahn, J. I..,Yoo, J. -Y..,Kim, T. H..,Kim, Y. I..,Ferguson, S. D..,...&Jeong, J. -W..(2016).cAMP-Response Element-Binding 3-Like Protein 1 (CREB3L1) is Required for Decidualization and its Expression is Decreased in Women with Endometriosis.CURRENT MOLECULAR MEDICINE,16(3),276-287.
MLA Ahn, J. I.,et al."cAMP-Response Element-Binding 3-Like Protein 1 (CREB3L1) is Required for Decidualization and its Expression is Decreased in Women with Endometriosis".CURRENT MOLECULAR MEDICINE 16.3(2016):276-287.
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