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This study aims at understanding the effect of soil texture and water quality (treated wastewater and groundwater) on soil physical (bulk density) and chemical (pH, salinity, CEC, total organic carbon and carbonate content) properties and on organic pollutant concentrations (polycyclic aromatic hydrocarbons) in different soil types in semi-arid regions. Results showed that the long-term irrigation with treated wastewater increased the bulk density in lithosoil and saline soil, while it decreased it in the isohumic soil. Moreover, the application of a double volume of treated wastewater enhanced the soil bulk density. However, irrigation with groundwater did not reveal any significant effect on soil bulk density. Also, the long-term impact of groundwater on the physico-chemical properties varies from one soil type to another. Multivariate analysis (principal component analysis) showed that different soil parameters such as soil texture and bulk density were determinant in soil evolution. The treated wastewater is considered as potential source of pollutants, and its long-term application induced high concentration of organic pollutant. Actually, the irrigated soils are heavily contaminated, and the carcinogenic molecule concentrations were about 1.2-7.6 times higher in these perimeters than in control soils.