Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.anai.2016.02.002 |
Effect of desert dust exposure on allergic symptoms A natural experiment in Japan | |
Kanatani, Kumiko T.1; Hamazaki, Kei2; Inadera, Hidekuni2; Sugimoto, Nobuo3; Shimizu, Atsushi4; Noma, Hisashi5,6; Onishi, Kazunari7; Takahashi, Yoshimitsu1,8; Itazawa, Toshiko9; Egawa, Miho10; Sato, Keiko11,12; Go, Tohshin12; Ito, Isao13; Kurozawa, Youichi7; Konishi, Ikuo10; Adachi, Yuichi9; Nakayama, Takeo1 | |
通讯作者 | Nakayama, Takeo |
来源期刊 | ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
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ISSN | 1081-1206 |
EISSN | 1534-4436 |
出版年 | 2016 |
卷号 | 116期号:5页码:425-+ |
英文摘要 | Background: Desert dust originating from arid and semiarid areas is transported to widespread regions, including Japan. Desert dust particles exert adjuvant effects in animals. Objective: To examine whether desert dust enhances allergic symptoms in real-life settings and to explore its effect modifiers. Methods: We conducted an observational study of 3,327 pregnant women during spring and fall in October 2011 to May 2013 in 3 regions in Japan as an adjunct study of the Japan Environment & Children’s Study. We acquired participants’ daily symptom scores by sending a questionnaire to their mobile phones on high desert-dust days (>0.07/km) and on some randomly selected other days (control days) for each participant. Results: Pregnant women had an increased risk of allergic symptoms on high desert-dust days (adjusted odds ratio [OR], 1.10; 95% CI, 1.04-1.18). The increased OR was mostly driven by those who showed positive IgE to Japanese cedar pollen when pollen simultaneously dispersed (adjusted OR, 1.25; 95% CI, 1.13-1.38), whereas no clear risk increase was observed in the absence of pollen or for participants with negative IgE to Japanese cedar pollen. The risk elevation was observed from low levels of desert dust in a dose-dependent manner even on control days. Conclusion: Ambient desert dust level was associated with an increased risk of allergic symptoms in pollen-sensitized pregnant women when pollen was present in the air. The risk increase was dose dependent and was observed from low levels of desert dust. These results support a hypothesis that ambient desert dust particles exert adjuvant effects in human in real-life settings. (C) 2016 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. |
类型 | Article |
语种 | 英语 |
国家 | Japan ; USA |
收录类别 | SCI-E |
WOS记录号 | WOS:000375860600010 |
WOS关键词 | ASIAN SAND DUST ; RHINITIS ; ASTHMA ; COEXPOSURE ; HEALTH |
WOS类目 | Allergy ; Immunology |
WOS研究方向 | Allergy ; Immunology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/191270 |
作者单位 | 1.Kyoto Univ, Sch Publ Hlth, Dept Hlth Informat, Kyoto, Japan; 2.Toyama Univ, Dept Publ Hlth, Toyama 930, Japan; 3.Natl Inst Environm Studies, Ctr Environm Measurement & Anal, Tsukuba, Ibaraki, Japan; 4.Natl Inst Environm Studies, Ctr Reg Environm Res, Tsukuba, Ibaraki, Japan; 5.Inst Stat Math, Dept Data Sci, Tokyo, Japan; 6.Kyoto Univ, Sch Publ Hlth, Dept Biostat, Kyoto, Japan; 7.Tottori Univ, Fac Med, Dept Social Med, Yonago, Tottori 683, Japan; 8.Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, 665 Huntington Ave, Boston, MA 02115 USA; 9.Toyama Univ, Fac Med, Dept Pediat, Toyama 930, Japan; 10.Kyoto Univ, Grad Sch Med, Dept Gynecol & Obstet, Kyoto, Japan; 11.Kyoto Univ Hosp, Inst Adv Clin & Translat Sci, Kyoto 606, Japan; 12.Kyoto Univ, Grad Sch Med, Ctr Japan Environm & Childrens Study, Kyoto Unit, Kyoto, Japan; 13.Kyoto Univ Hosp, Dept Resp Med, Kyoto 606, Japan |
推荐引用方式 GB/T 7714 | Kanatani, Kumiko T.,Hamazaki, Kei,Inadera, Hidekuni,et al. Effect of desert dust exposure on allergic symptoms A natural experiment in Japan[J],2016,116(5):425-+. |
APA | Kanatani, Kumiko T..,Hamazaki, Kei.,Inadera, Hidekuni.,Sugimoto, Nobuo.,Shimizu, Atsushi.,...&Nakayama, Takeo.(2016).Effect of desert dust exposure on allergic symptoms A natural experiment in Japan.ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY,116(5),425-+. |
MLA | Kanatani, Kumiko T.,et al."Effect of desert dust exposure on allergic symptoms A natural experiment in Japan".ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY 116.5(2016):425-+. |
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