Arid
DOI10.1016/j.aca.2016.01.056
Target and suspect screening of psychoactive substances in sewage-based samples by UHPLC-QTOF
Baz-Lomba, J. A.1,2; Reid, Malcolm J.1; Thomas, Kevin V.1
通讯作者Baz-Lomba, J. A.
来源期刊ANALYTICA CHIMICA ACTA
ISSN0003-2670
EISSN1873-4324
出版年2016
卷号914页码:81-90
英文摘要

The quantification of illicit drug and pharmaceutical residues in sewage has been shown to be a valuable tool that complements existing approaches in monitoring the patterns and trends of drug use. The present work delineates the development of a novel analytical tool and dynamic workflow for the analysis of a wide range of substances in sewage-based samples. The validated method can simultaneously quantify 51 target psychoactive substances and pharmaceuticals in sewage-based samples using an off-line automated solid phase extraction (SPE-DEX) method, using Oasis HLB disks, followed by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-QTOF) in MSe. Quantification and matrix effect corrections were overcome with the use of 25 isotopic labeled internal standards (ILIS). Recoveries were generally greater than 60% and the limits of quantification were in the low nanogram-per-liter range (0.4-187 ng L-1). The emergence of new psychoactive substances (NPS) on the drug scene poses a specific analytical challenge since their market is highly dynamic with new compounds continuously entering the market. Suspect screening using high-resolution mass spectrometry (HRMS) simultaneously allowed the unequivocal identification of NPS based on a mass accuracy criteria of 5 ppm (of the molecular ion and at least two fragments) and retention time (2.5% tolerance) using the UNIFI screening platform. Applying MSe data against a suspect screening database of over 1000 drugs and metabolites, this method becomes a broad and reliable tool to detect and confirm NPS occurrence. This was demonstrated through the HRMS analysis of three different sewage-based sample types; influent wastewater, passive sampler extracts and pooled urine samples resulting in the concurrent quantification of known psychoactive substances and the identification of NPS and pharmaceuticals. (C) 2016 Elsevier B.V. All rights reserved.


英文关键词High resolution mass spectrometry Sewage-base epidemiology Multi-residue method Dynamic workflow Screening Psychoactive drugs
类型Article
语种英语
国家Norway
收录类别SCI-E
WOS记录号WOS:000371348100009
WOS关键词RESOLUTION MASS-SPECTROMETRY ; WASTE-WATER TREATMENT ; COMMUNITY DRUG-USE ; ILLICIT DRUGS ; SYNTHETIC CANNABINOIDS ; CONSUMPTION PATTERNS ; PHARMACEUTICALS ; METABOLITES ; BIOMARKERS ; MS/MS
WOS类目Chemistry, Analytical
WOS研究方向Chemistry
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/191239
作者单位1.Norwegian Inst Water Res, Gaustadalleen 21, NO-0349 Oslo, Norway;
2.Univ Oslo, Fac Med, POB 1078, N-0316 Oslo, Norway
推荐引用方式
GB/T 7714
Baz-Lomba, J. A.,Reid, Malcolm J.,Thomas, Kevin V.. Target and suspect screening of psychoactive substances in sewage-based samples by UHPLC-QTOF[J],2016,914:81-90.
APA Baz-Lomba, J. A.,Reid, Malcolm J.,&Thomas, Kevin V..(2016).Target and suspect screening of psychoactive substances in sewage-based samples by UHPLC-QTOF.ANALYTICA CHIMICA ACTA,914,81-90.
MLA Baz-Lomba, J. A.,et al."Target and suspect screening of psychoactive substances in sewage-based samples by UHPLC-QTOF".ANALYTICA CHIMICA ACTA 914(2016):81-90.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Baz-Lomba, J. A.]的文章
[Reid, Malcolm J.]的文章
[Thomas, Kevin V.]的文章
百度学术
百度学术中相似的文章
[Baz-Lomba, J. A.]的文章
[Reid, Malcolm J.]的文章
[Thomas, Kevin V.]的文章
必应学术
必应学术中相似的文章
[Baz-Lomba, J. A.]的文章
[Reid, Malcolm J.]的文章
[Thomas, Kevin V.]的文章
相关权益政策
暂无数据
收藏/分享

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。