Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.aca.2016.01.056 |
Target and suspect screening of psychoactive substances in sewage-based samples by UHPLC-QTOF | |
Baz-Lomba, J. A.1,2; Reid, Malcolm J.1; Thomas, Kevin V.1 | |
通讯作者 | Baz-Lomba, J. A. |
来源期刊 | ANALYTICA CHIMICA ACTA
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ISSN | 0003-2670 |
EISSN | 1873-4324 |
出版年 | 2016 |
卷号 | 914页码:81-90 |
英文摘要 | The quantification of illicit drug and pharmaceutical residues in sewage has been shown to be a valuable tool that complements existing approaches in monitoring the patterns and trends of drug use. The present work delineates the development of a novel analytical tool and dynamic workflow for the analysis of a wide range of substances in sewage-based samples. The validated method can simultaneously quantify 51 target psychoactive substances and pharmaceuticals in sewage-based samples using an off-line automated solid phase extraction (SPE-DEX) method, using Oasis HLB disks, followed by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-QTOF) in MSe. Quantification and matrix effect corrections were overcome with the use of 25 isotopic labeled internal standards (ILIS). Recoveries were generally greater than 60% and the limits of quantification were in the low nanogram-per-liter range (0.4-187 ng L-1). The emergence of new psychoactive substances (NPS) on the drug scene poses a specific analytical challenge since their market is highly dynamic with new compounds continuously entering the market. Suspect screening using high-resolution mass spectrometry (HRMS) simultaneously allowed the unequivocal identification of NPS based on a mass accuracy criteria of 5 ppm (of the molecular ion and at least two fragments) and retention time (2.5% tolerance) using the UNIFI screening platform. Applying MSe data against a suspect screening database of over 1000 drugs and metabolites, this method becomes a broad and reliable tool to detect and confirm NPS occurrence. This was demonstrated through the HRMS analysis of three different sewage-based sample types; influent wastewater, passive sampler extracts and pooled urine samples resulting in the concurrent quantification of known psychoactive substances and the identification of NPS and pharmaceuticals. (C) 2016 Elsevier B.V. All rights reserved. |
英文关键词 | High resolution mass spectrometry Sewage-base epidemiology Multi-residue method Dynamic workflow Screening Psychoactive drugs |
类型 | Article |
语种 | 英语 |
国家 | Norway |
收录类别 | SCI-E |
WOS记录号 | WOS:000371348100009 |
WOS关键词 | RESOLUTION MASS-SPECTROMETRY ; WASTE-WATER TREATMENT ; COMMUNITY DRUG-USE ; ILLICIT DRUGS ; SYNTHETIC CANNABINOIDS ; CONSUMPTION PATTERNS ; PHARMACEUTICALS ; METABOLITES ; BIOMARKERS ; MS/MS |
WOS类目 | Chemistry, Analytical |
WOS研究方向 | Chemistry |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/191239 |
作者单位 | 1.Norwegian Inst Water Res, Gaustadalleen 21, NO-0349 Oslo, Norway; 2.Univ Oslo, Fac Med, POB 1078, N-0316 Oslo, Norway |
推荐引用方式 GB/T 7714 | Baz-Lomba, J. A.,Reid, Malcolm J.,Thomas, Kevin V.. Target and suspect screening of psychoactive substances in sewage-based samples by UHPLC-QTOF[J],2016,914:81-90. |
APA | Baz-Lomba, J. A.,Reid, Malcolm J.,&Thomas, Kevin V..(2016).Target and suspect screening of psychoactive substances in sewage-based samples by UHPLC-QTOF.ANALYTICA CHIMICA ACTA,914,81-90. |
MLA | Baz-Lomba, J. A.,et al."Target and suspect screening of psychoactive substances in sewage-based samples by UHPLC-QTOF".ANALYTICA CHIMICA ACTA 914(2016):81-90. |
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