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Net primary productivity (NPP) lays the foundation for provision of various ecosystem services, and understanding the impacts of potential influencing factors on NPP is of great significance to formulating appropriate management measures to guarantee the sustainable provision of essential ecosystem services. This study analyzed the impacts of potential influencing factors on NPP in the lower Heihe River Basin, a typical arid and semi-arid region in China. First, NPP was estimated with the C-FIX model, and then the multilevel model was used to analyze the impacts of potential influencing factors on NPP during 2000-2008. Finally decomposition analysis was used to further analyze the contribution of influencing factors to NPP change during 2000-2008. The average NPP increased by approximately 9.07% during 2000-2008, and results of the multilevel model indicate that both the socioeconomic variables and demographic variables are useful in explaining NPP change. In particular, coefficients of rainfall and evapotranspiration which represent the water availability reached 0.0456 and 0.2956, respectively. Results of decomposition analysis suggested that the water availability played an important role in increasing NPP, with a contribution rate of 44.17%, and it is necessary to carry out some policies that can promote the water use efficiency to increase NPP under the background of climate change and intensified human activities. There are some uncertainties in the results of this study, but these results still can provide valuable reference information for the water resource management to increase the ecosystem service supply in the lower Heihe River Basin. (C) 2015 Elsevier Ltd. All rights reserved.