Arid
DOI10.1016/j.neubiorev.2014.09.017
The opportunities and challenges of large-scale molecular approaches to songbird neurobiology
Mello, C. V.1; Clayton, D. F.2
通讯作者Mello, C. V.
来源期刊NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
ISSN0149-7634
EISSN1873-7528
出版年2015
卷号50页码:70-76
英文摘要

High-throughput methods for analyzing genome structure and function are having a large impact in songbird neurobiology. Methods include genome sequencing and annotation, comparative genomics, DNA microarrays and transcriptomics, and the development of a brain atlas of gene expression. Key emerging findings include the identification of complex transcriptional programs active during singing, the robust brain expression of non-coding RNAs, evidence of profound variations in gene expression across brain regions, and the identification of molecular specializations within song production and learning circuits. Current challenges include the statistical analysis of large datasets, effective genome curations, the efficient localization of gene expression changes to specific neuronal circuits arid cells, and the dissection of behavioral and environmental factors that influence brain gene expression. The field requires efficient methods for comparisons with organisms like chicken, which offer important anatomical, functional and behavioral contrasts. As sequencing costs plummet, opportunities emerge for comparative approaches that may help reveal evolutionary transitions contributing to vocal learning, social behavior and other properties that make songbirds such compelling research subjects. (C) 2014 Elsevier Ltd. All rights reserved.


英文关键词Songbirds Zebra finch Gene expression Vocal learning Genomics Transcriptomics Microarrays High-throughput Birdsong Networks Avian models
类型Review
语种英语
国家USA ; England
收录类别SCI-E
WOS记录号WOS:000351974000007
WOS关键词FINCH TAENIOPYGIA-GUTTATA ; GENE-EXPRESSION PROFILES ; BASAL GANGLIA CIRCUIT ; UNION-OF-PHARMACOLOGY ; ADULT ZEBRA FINCHES ; AUDITORY FOREBRAIN ; CAUDOMEDIAL NEOSTRIATUM ; POTASSIUM CHANNELS ; CONSPECIFIC SONG ; SOCIAL-BEHAVIOR
WOS类目Behavioral Sciences ; Neurosciences
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
来源机构University of London
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/189359
作者单位1.Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA;
2.Queen Mary Univ London, Sch Biol & Chem Sci, Div Biol & Expt Psychol, London E1 4NS, England
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GB/T 7714
Mello, C. V.,Clayton, D. F.. The opportunities and challenges of large-scale molecular approaches to songbird neurobiology[J]. University of London,2015,50:70-76.
APA Mello, C. V.,&Clayton, D. F..(2015).The opportunities and challenges of large-scale molecular approaches to songbird neurobiology.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,50,70-76.
MLA Mello, C. V.,et al."The opportunities and challenges of large-scale molecular approaches to songbird neurobiology".NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 50(2015):70-76.
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