Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.neubiorev.2014.09.017 |
The opportunities and challenges of large-scale molecular approaches to songbird neurobiology | |
Mello, C. V.1; Clayton, D. F.2 | |
通讯作者 | Mello, C. V. |
来源期刊 | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
![]() |
ISSN | 0149-7634 |
EISSN | 1873-7528 |
出版年 | 2015 |
卷号 | 50页码:70-76 |
英文摘要 | High-throughput methods for analyzing genome structure and function are having a large impact in songbird neurobiology. Methods include genome sequencing and annotation, comparative genomics, DNA microarrays and transcriptomics, and the development of a brain atlas of gene expression. Key emerging findings include the identification of complex transcriptional programs active during singing, the robust brain expression of non-coding RNAs, evidence of profound variations in gene expression across brain regions, and the identification of molecular specializations within song production and learning circuits. Current challenges include the statistical analysis of large datasets, effective genome curations, the efficient localization of gene expression changes to specific neuronal circuits arid cells, and the dissection of behavioral and environmental factors that influence brain gene expression. The field requires efficient methods for comparisons with organisms like chicken, which offer important anatomical, functional and behavioral contrasts. As sequencing costs plummet, opportunities emerge for comparative approaches that may help reveal evolutionary transitions contributing to vocal learning, social behavior and other properties that make songbirds such compelling research subjects. (C) 2014 Elsevier Ltd. All rights reserved. |
英文关键词 | Songbirds Zebra finch Gene expression Vocal learning Genomics Transcriptomics Microarrays High-throughput Birdsong Networks Avian models |
类型 | Review |
语种 | 英语 |
国家 | USA ; England |
收录类别 | SCI-E |
WOS记录号 | WOS:000351974000007 |
WOS关键词 | FINCH TAENIOPYGIA-GUTTATA ; GENE-EXPRESSION PROFILES ; BASAL GANGLIA CIRCUIT ; UNION-OF-PHARMACOLOGY ; ADULT ZEBRA FINCHES ; AUDITORY FOREBRAIN ; CAUDOMEDIAL NEOSTRIATUM ; POTASSIUM CHANNELS ; CONSPECIFIC SONG ; SOCIAL-BEHAVIOR |
WOS类目 | Behavioral Sciences ; Neurosciences |
WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology |
来源机构 | University of London |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/189359 |
作者单位 | 1.Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA; 2.Queen Mary Univ London, Sch Biol & Chem Sci, Div Biol & Expt Psychol, London E1 4NS, England |
推荐引用方式 GB/T 7714 | Mello, C. V.,Clayton, D. F.. The opportunities and challenges of large-scale molecular approaches to songbird neurobiology[J]. University of London,2015,50:70-76. |
APA | Mello, C. V.,&Clayton, D. F..(2015).The opportunities and challenges of large-scale molecular approaches to songbird neurobiology.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,50,70-76. |
MLA | Mello, C. V.,et al."The opportunities and challenges of large-scale molecular approaches to songbird neurobiology".NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 50(2015):70-76. |
条目包含的文件 | 条目无相关文件。 |
个性服务 |
推荐该条目 |
保存到收藏夹 |
导出为Endnote文件 |
谷歌学术 |
谷歌学术中相似的文章 |
[Mello, C. V.]的文章 |
[Clayton, D. F.]的文章 |
百度学术 |
百度学术中相似的文章 |
[Mello, C. V.]的文章 |
[Clayton, D. F.]的文章 |
必应学术 |
必应学术中相似的文章 |
[Mello, C. V.]的文章 |
[Clayton, D. F.]的文章 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。