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Myxomycetes from 10 localities in the central plains of the Sonoran desert were studied using the moist chamber culture technique. Thirty-three species have been identified, of which five (Comatricha mirabilis, Cribraria confusa, Didymium eremophilum, Perichaena luteola, and P. stipitata) represent new records for Sonora, and Comatricha mirabilis is cited for the first time from Mexico. Light and scanning electron microphotographs illustrate the most diagnostic characters of these species, which are rare or scarcely mentioned in the literature.