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Arid and semiarid lowland areas of central Asia are largely dependent on fluvial water originating from the Tian Shan. Mountain glaciers contribute significantly to runoff, particularly in summer. With global warming, the total glacier area in the Kunma Like River catchment declined by 13.2% during 1990-2007. For future water resources, it is essential to quantify the responses of hydrologic processes to both climate change and shrinking glaciers in glacierized catchments, such as the headwaters of the Tarim River. Thus, a degree-day glacier melt algorithm was integrated into the macroscale hydrologic Variable Infiltration Capacity model (VIC). Good results were obtained for monthly runoff simulations in the Kunma Like River catchment, which suggest that the extended VIC has acceptable performance. Because of increased precipitation and air temperature, annual runoff in the catchment has increased by about 4.07 x 10(8) m(3) decade(-1) during 1984/85-2006/07. Under the assumption of the same climatic conditions, sensitivity analyses indicated that annual and summer river runoff volumes would decrease by 9.3% and 10.4%, respectively, for reductions in glacier area of 13.2%. The variation coefficient of annual runoff also increased because of shrinking glaciers. Runoff scenarios for warmer future climate and various deglaciation situations suggest that reductions in glacier area by >30% will likely produce less meltwater in summer and river runoff will decline. Consequently, the annual total discharge of the Kunma Like River is projected to decrease by 2.8%-19.4% in the 2050s scenario because of glacier shrinking.