Arid
DOI10.1016/j.jaridenv.2014.01.007
Snapshots of scorpion venomics
Abdel-Rahman, Mohamed A.1,2; Harrison, Patrick L.2; Strong, Peter N.2
通讯作者Harrison, Patrick L.
来源期刊JOURNAL OF ARID ENVIRONMENTS
ISSN0140-1963
EISSN1095-922X
出版年2015
卷号112页码:170-176
英文摘要

Scorpions are particularly well adapted to survival in extreme habitats (especially arid and semi-arid environments) and their ability to produce and deliver venoms is an important factor in this success. Scorpion venoms are very complex mixtures of different proteins and peptides. Previous venomics studies revealed that each one of scorpion species may contain more than 100 different peptides. Scorpion venom peptides can be classified into two main types: disulfide-bridged peptides (DBPs) and non-disulfide-bridged peptides (NDBPs). The vast majority of DBPs are neurotoxic peptides that specifically interact with various types of ion-channels. The NDBPs have been shown to variously possess bradykinin-potentiating, antimicrobial, hemolytic, cellular signaling and immune-modulating activities. Recently, venom proteomics have been extensively applied in assessing the diversity of scorpion venom from various species. More insights about scorpion venom compositions were also gained through transcriptomic approach. It has provided an opportunity to obtain an overview of the content of scorpion venoms and to compare the relative abundance of toxin transcripts. More importantly, transcriptomics can reflect the biological processes occurring in venom gland cells. This review will highlight recent proteomic and transcriptomic studies to explore the venome of scorpions from different habitats, focusing on desert scorpions from North Africa. (C) 2014 Elsevier Ltd. All rights reserved.


英文关键词Desert environment Proteomics Toxin peptides Transcriptomics Venome
类型Article
语种英语
国家Egypt ; England
收录类别SCI-E
WOS记录号WOS:000346548900010
WOS关键词MASS-SPECTROMETRY ANALYSIS ; AMINO-ACID-SEQUENCE ; PROTEOMIC ANALYSIS ; TRANSCRIPTOMIC ANALYSIS ; ANTIMICROBIAL PEPTIDES ; MOLECULAR DIVERSITY ; GATING MODIFIER ; TOXIC FRACTIONS ; CDNA SEQUENCES ; SNAKE VENOMICS
WOS类目Ecology ; Environmental Sciences
WOS研究方向Environmental Sciences & Ecology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/188278
作者单位1.Suez Canal Univ, Fac Sci, Dept Zool, Ismailia 41522, Egypt;
2.Sheffield Hallam Univ, Biosci Div, Biomed Res Ctr, Sheffield S1 1WB, S Yorkshire, England
推荐引用方式
GB/T 7714
Abdel-Rahman, Mohamed A.,Harrison, Patrick L.,Strong, Peter N.. Snapshots of scorpion venomics[J],2015,112:170-176.
APA Abdel-Rahman, Mohamed A.,Harrison, Patrick L.,&Strong, Peter N..(2015).Snapshots of scorpion venomics.JOURNAL OF ARID ENVIRONMENTS,112,170-176.
MLA Abdel-Rahman, Mohamed A.,et al."Snapshots of scorpion venomics".JOURNAL OF ARID ENVIRONMENTS 112(2015):170-176.
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