Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.jaridenv.2014.01.007 |
Snapshots of scorpion venomics | |
Abdel-Rahman, Mohamed A.1,2; Harrison, Patrick L.2; Strong, Peter N.2 | |
通讯作者 | Harrison, Patrick L. |
来源期刊 | JOURNAL OF ARID ENVIRONMENTS
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ISSN | 0140-1963 |
EISSN | 1095-922X |
出版年 | 2015 |
卷号 | 112页码:170-176 |
英文摘要 | Scorpions are particularly well adapted to survival in extreme habitats (especially arid and semi-arid environments) and their ability to produce and deliver venoms is an important factor in this success. Scorpion venoms are very complex mixtures of different proteins and peptides. Previous venomics studies revealed that each one of scorpion species may contain more than 100 different peptides. Scorpion venom peptides can be classified into two main types: disulfide-bridged peptides (DBPs) and non-disulfide-bridged peptides (NDBPs). The vast majority of DBPs are neurotoxic peptides that specifically interact with various types of ion-channels. The NDBPs have been shown to variously possess bradykinin-potentiating, antimicrobial, hemolytic, cellular signaling and immune-modulating activities. Recently, venom proteomics have been extensively applied in assessing the diversity of scorpion venom from various species. More insights about scorpion venom compositions were also gained through transcriptomic approach. It has provided an opportunity to obtain an overview of the content of scorpion venoms and to compare the relative abundance of toxin transcripts. More importantly, transcriptomics can reflect the biological processes occurring in venom gland cells. This review will highlight recent proteomic and transcriptomic studies to explore the venome of scorpions from different habitats, focusing on desert scorpions from North Africa. (C) 2014 Elsevier Ltd. All rights reserved. |
英文关键词 | Desert environment Proteomics Toxin peptides Transcriptomics Venome |
类型 | Article |
语种 | 英语 |
国家 | Egypt ; England |
收录类别 | SCI-E |
WOS记录号 | WOS:000346548900010 |
WOS关键词 | MASS-SPECTROMETRY ANALYSIS ; AMINO-ACID-SEQUENCE ; PROTEOMIC ANALYSIS ; TRANSCRIPTOMIC ANALYSIS ; ANTIMICROBIAL PEPTIDES ; MOLECULAR DIVERSITY ; GATING MODIFIER ; TOXIC FRACTIONS ; CDNA SEQUENCES ; SNAKE VENOMICS |
WOS类目 | Ecology ; Environmental Sciences |
WOS研究方向 | Environmental Sciences & Ecology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/188278 |
作者单位 | 1.Suez Canal Univ, Fac Sci, Dept Zool, Ismailia 41522, Egypt; 2.Sheffield Hallam Univ, Biosci Div, Biomed Res Ctr, Sheffield S1 1WB, S Yorkshire, England |
推荐引用方式 GB/T 7714 | Abdel-Rahman, Mohamed A.,Harrison, Patrick L.,Strong, Peter N.. Snapshots of scorpion venomics[J],2015,112:170-176. |
APA | Abdel-Rahman, Mohamed A.,Harrison, Patrick L.,&Strong, Peter N..(2015).Snapshots of scorpion venomics.JOURNAL OF ARID ENVIRONMENTS,112,170-176. |
MLA | Abdel-Rahman, Mohamed A.,et al."Snapshots of scorpion venomics".JOURNAL OF ARID ENVIRONMENTS 112(2015):170-176. |
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