Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1007/s00216-015-8796-x |
LC-QTOF MS screening of more than 1,000 licit and illicit drugs and their metabolites in wastewater and surface waters from the area of Bogota, Colombia | |
Hernandez, Felix1; Ibanez, Maria1; Botero-Coy, Ana-Maria1; Bade, Richard1; Cristina Bustos-Lopez, Martha2; Rincon, Javier3; Moncayo, Alejandro3; Bijlsma, Lubertus1 | |
通讯作者 | Hernandez, Felix |
来源期刊 | ANALYTICAL AND BIOANALYTICAL CHEMISTRY |
ISSN | 1618-2642 |
EISSN | 1618-2650 |
出版年 | 2015 |
卷号 | 407期号:21页码:6405-6416 |
英文摘要 | A large screening of around 1,000 emerging contaminants, focused on licit and illicit drugs and their metabolites, has been made in urban wastewaters (both influent and effluent) and surface waters from the area of Bogota, Colombia. After a simple generic solid-phase extraction (SPE) step with Oasis hydrophilic-lipophilic balanced (HLB) cartridges, analyses were made by ultra high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-QTOF MS) under MSE mode (sequential acquisition of mass spectra at low energy (LE) and high collision energy (HE)). Accurate mass measurements and the information provided by MSE on the presence of the (de)protonated molecule and fragment ions allowed the reliable identification of the compounds detected, even without reference standards being available in some cases (tentative identification). The compounds most frequently found were acetaminophen/paracetamol, carbamazepine and its dihydro-dihydroxylated metabolite, clarithromycin, diclofenac, ibuprofen, gemfibrozil, lincomycin, losartan, valsartan, the two metabolites of metamizole (4-acetamido-antipyrine and 4-formylamino-antipyrine), sucralose, and cocaine and its main metabolite benzoylecgonine. Caffeine, the sweetener saccharin, and two hydroxylated metabolites of losartan were tentatively identified in almost all samples analyzed. Pharmaceutical lidocaine was tentatively identified and subsequently confirmed with reference standard. For the first time, a general overview of the occurrence of drugs and their metabolites in the aquatic environment of Colombia has been reported. In the near future, target methodologies, typically based on liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), will need to be set up for accurate and sensitive quantification of the contaminants selected on the basis on the information provided in the present paper. |
英文关键词 | Screening Ultra high-performance liquid chromatography Time-of-flight mass spectrometry Drugs Water Colombia |
类型 | Article |
语种 | 英语 |
国家 | Spain ; Colombia |
收录类别 | SCI-E |
WOS记录号 | WOS:000358646400015 |
WOS关键词 | PERSONAL CARE PRODUCTS ; EMERGING CONTAMINANTS ; PHARMACEUTICALS ; SAMPLES ; STRATEGIES ; COCAINE ; ABUSE |
WOS类目 | Biochemical Research Methods ; Chemistry, Analytical |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/185721 |
作者单位 | 1.Univ Jaume 1, Res Inst Pesticides & Water, Castellon de La Plana 12071, Spain; 2.Univ Nacl Colombia, Dept Ingn Civil & Agr, Bogota 111321, Colombia; 3.Univ Antonio Narino, Fac Ciencias, Dept Quim, Bogota 111511, Colombia |
推荐引用方式 GB/T 7714 | Hernandez, Felix,Ibanez, Maria,Botero-Coy, Ana-Maria,et al. LC-QTOF MS screening of more than 1,000 licit and illicit drugs and their metabolites in wastewater and surface waters from the area of Bogota, Colombia[J],2015,407(21):6405-6416. |
APA | Hernandez, Felix.,Ibanez, Maria.,Botero-Coy, Ana-Maria.,Bade, Richard.,Cristina Bustos-Lopez, Martha.,...&Bijlsma, Lubertus.(2015).LC-QTOF MS screening of more than 1,000 licit and illicit drugs and their metabolites in wastewater and surface waters from the area of Bogota, Colombia.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,407(21),6405-6416. |
MLA | Hernandez, Felix,et al."LC-QTOF MS screening of more than 1,000 licit and illicit drugs and their metabolites in wastewater and surface waters from the area of Bogota, Colombia".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 407.21(2015):6405-6416. |
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