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The paper assessed the sensitivity of an integrated hydro-economic model, to provide a quantitative range of uncertainty in the impacts of climate change on water balance components and water use in the agricultural sector of Apulia region located in a semi-arid Mediterranean climate area in southern Italy. Results show that the impacts of climate change are expressed in the future by an increase in the net irrigation requirements (NIRs) of all crops. Total cultivated land is reduced by 8.5 % in the future, and the percentage of irrigated land decreases from 31 to 22 % of total agricultural land. Reduction in the irrigated land, together with the variation in the cropping pattern and the adoption of the different irrigation techniques, led to a decrease in water demand for irrigation across the entire region. The sensitivity analysis shows that the groundwater recharge has the lowest correlation to climatic parameters. Results are addressed to the scientific community and decision makers to support the design of adequate adaptation policies for efficient water management under the severe drought conditions that are likely to occur in the region according to climate change projections.