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The objective of the present study was to investigate the effect of ofloxacin (10 mg/kg) on the pharmacokinetics of meloxicam (0.5 mg/kg) in goats, when administered concurrently by intravenous route. Meloxicam concentration in plasma -was measured using HPLC assay. The pharmacolcinetics of meloxicam were best described by the two-compartment open model. Following concurrent administration of meloxicam and ofioxacin, the mean plasma level of meloxicam was only found to be significantly higher (P<0.05) at 15 mm compared to its alone administration. Statistical analysis of data revealed that there were no statistically significant differences in PK parameters between the two treatments, except K-21 Therefore, the results of the present study suggest that concurrent administration of ofloxacin and meloxicam in goats does not require any adjustment in dosage regimens. Based on PK determinants, meloxicam may be administered by i.v. route at 0.86 and 0.65 mg/kg, as loading and maintenance doses respectively, and is to be repeated at 8 h intervals.