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| DOI | 10.1073/pnas.1400350111 |
| Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5 | |
| Kim, Taewan1; Cui, Ri1,4; Jeon, Young-Jun1; Lee, Ji-Hoon5; Lee, Ju Hee6; Sim, Hosung7; Park, Jong Kook8; Fadda, Paolo1; Tili, Esmerina1,2; Nakanishi, Hiroshi1; Huh, Man-Il9; Kim, Sung-Hak3,10; Cho, Ju Hwan11; Sung, Bong Hwan12; Peng, Yong1; Lee, Tae Jin1; Luo, Zhenghua1; Sun, Hui-Lung1; Wei, Huijun1; Alder, Hansjuerg1; Oh, Jeong Su13; Shim, Kang Sup1; Ko, Sang-Bong14; Croce, Carlo M.1 | |
| 通讯作者 | Croce, Carlo M. |
| 来源期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| ISSN | 0027-8424 |
| 出版年 | 2014 |
| 卷号 | 111期号:11页码:4173-4178 |
| 英文摘要 | The mechanism by which the 8q24 MYC enhancer region, including cancer-associated variant rs6983267, increases cancer risk is unknown due to the lack of protein-coding genes at 8q24.21. Here we report the identification of long noncoding RNAs named cancer-associated region long noncoding RNAs (CARLos) in the 8q24 region. The expression of one of the long noncoding RNAs, CARLo-5, is significantly correlated with the rs6983267 allele associated with increased cancer susceptibility. We also found the MYC enhancer region physically interacts with the active regulatory region of the CARLo-5 promoter, suggesting long-range interaction of MYC enhancer with the CARLo-5 promoter regulates CARLo-5 expression. Finally, we demonstrate that CARLo-5 has a function in cell-cycle regulation and tumor development. Overall, our data provide a key of the mystery of the 8q24 gene desert. |
| 类型 | Article |
| 语种 | 英语 |
| 国家 | USA ; Peoples R China ; South Korea |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000333027900066 |
| WOS关键词 | GENOME-WIDE ASSOCIATION ; COLORECTAL-CANCER ; PROSTATE-CANCER ; SNP RS6983267 ; CHROMOSOME 8Q24 ; COLON-CANCER ; RISK LOCUS ; EXPRESSION ; VARIANT ; TISSUE |
| WOS类目 | Multidisciplinary Sciences |
| WOS研究方向 | Science & Technology - Other Topics |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/184465 |
| 作者单位 | 1.Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA; 2.Ohio State Univ, Wexner Med Ctr, Dept Anesthesiol, Columbus, OH 43210 USA; 3.Ohio State Univ, Dept Neurol Surg, Columbus, OH 43210 USA; 4.YanBian Univ, Dept Pathol, Affiliated Hosp, Yanji 133002, Peoples R China; 5.Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75235 USA; 6.Univ Calif Santa Cruz, Dept Appl Math & Stat, Santa Cruz, CA 95064 USA; 7.Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA; 8.Northwestern Univ, Dept Dermatol, Chicago, IL 60208 USA; 9.Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Taegu 700842, South Korea; 10.Korea Univ, Sch Life Sci & Biotechnol, Seoul 136702, South Korea; 11.Ohio State Univ, Med Ctr, Arthur G James Comprehens Canc Ctr, Dept Radiat Oncol, Columbus, OH 43210 USA; 12.Vanderbilt Univ, Med Ctr, Dept Canc Biol, Nashville, TN 37232 USA; 13.Sungkyunkwan Univ, Dept Genet Engn, Suwon 110745, South Korea; 14.Catholic Univ Daegu, Sch Med, Daegu Catholic Univ, Dept Orthoped Surg,Med Ctr, Taegu 705718, South Korea |
| 推荐引用方式 GB/T 7714 | Kim, Taewan,Cui, Ri,Jeon, Young-Jun,et al. Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5[J],2014,111(11):4173-4178. |
| APA | Kim, Taewan.,Cui, Ri.,Jeon, Young-Jun.,Lee, Ji-Hoon.,Lee, Ju Hee.,...&Croce, Carlo M..(2014).Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,111(11),4173-4178. |
| MLA | Kim, Taewan,et al."Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111.11(2014):4173-4178. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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