Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1080/14786419.2013.856904 |
Brazilian brown propolis elicits antileishmanial effect against promastigote and amastigote forms of Leishmania amazonensis | |
Santana, Lorena C. L. R.1; Carneiro, Sabrina Maria P.1; Caland-Neto, Laurentino B.2; Arcanjo, Daniel D. R.1; Moita-Neto, Jose M.2; Cito, Antonia M. G. L.2; Carvalho, Fernando Aecio A.1,3 | |
通讯作者 | Carvalho, Fernando Aecio A. |
来源期刊 | NATURAL PRODUCT RESEARCH
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ISSN | 1478-6419 |
EISSN | 1478-6427 |
出版年 | 2014 |
卷号 | 28期号:5页码:340-343 |
英文摘要 | Propolis is a complex matrix of chemical constituents extracted from plants and produced by bees which is used in folk medicine due to its several pharmacological properties. Its chemical composition varies according to the region where it is produced. This work has studied the antileishmanial activity and cytotoxicity of brown propolis (BP) originating from the semi-arid region of Piaui, Brazil. The BP showed significant inhibition of the Leishmania amazonensis promastigotes growth as well as being effective in reducing infection of murine macrophages and the number of internalised amastigotes in these cells. The dichloromethane fraction was the most active and showed the best selectivity index. The studied samples presented good activity and the fractioning improved the antileishmanial activity without an increase in the cytotoxicity against mammalian cells. Therefore, BP is a potential source for development of apitherapeutic products for the treatment of leishmaniasis. |
英文关键词 | leishmaniasis antiparasitic activity cytotoxicity propolis brown propolis |
类型 | Article |
语种 | 英语 |
国家 | Brazil |
收录类别 | SCI-E |
WOS记录号 | WOS:000333994100012 |
WOS类目 | Chemistry, Applied ; Chemistry, Medicinal |
WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/183948 |
作者单位 | 1.Univ Fed Piaui, Med Plants Res Ctr, Teresina, PI, Brazil; 2.Univ Fed Piaui, Dept Chem, Teresina, PI, Brazil; 3.Univ Fed Piaui, Dept Biochem & Pharmacol, Teresina, PI, Brazil |
推荐引用方式 GB/T 7714 | Santana, Lorena C. L. R.,Carneiro, Sabrina Maria P.,Caland-Neto, Laurentino B.,et al. Brazilian brown propolis elicits antileishmanial effect against promastigote and amastigote forms of Leishmania amazonensis[J],2014,28(5):340-343. |
APA | Santana, Lorena C. L. R..,Carneiro, Sabrina Maria P..,Caland-Neto, Laurentino B..,Arcanjo, Daniel D. R..,Moita-Neto, Jose M..,...&Carvalho, Fernando Aecio A..(2014).Brazilian brown propolis elicits antileishmanial effect against promastigote and amastigote forms of Leishmania amazonensis.NATURAL PRODUCT RESEARCH,28(5),340-343. |
MLA | Santana, Lorena C. L. R.,et al."Brazilian brown propolis elicits antileishmanial effect against promastigote and amastigote forms of Leishmania amazonensis".NATURAL PRODUCT RESEARCH 28.5(2014):340-343. |
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