Arid
DOI10.1093/mmy/myt001
Genomics in Coccidioides: Insights into evolution, ecology, and pathogenesis
Whiston, Emily; Taylor, John W.
通讯作者Whiston, Emily
来源期刊MEDICAL MYCOLOGY
ISSN1369-3786
EISSN1460-2709
出版年2014
卷号52期号:2页码:149-155
英文摘要

Coccidioides immitis and C. posadasii, the causative agents of the mammalian disease coccidioidomycosis, are dimorphic fungal pathogens distributed throughout desert-like environments in North and South America. Coccidioides spp. are members of the Onygenales, a diverse group of pathogenic and nonpathogenic fungi. Recently, full genomes have been published for Coccidioides and a number of other Onygenales species. Phylogenomic comparisons and additional studies in Coccidioides population genomics and gene expression have shed light on the ecology and pathogenesis of Coccidioides and the other medically important species in this clade. Observed patterns of gene family expansion/contraction and evidence of gene flow have provided insight to the evolution of Coccidioides and greatly broadened our understanding of the diversity and sources of genetic variation found in fungi. In the future, expansion of the number of sequenced isolates from all populations will allow deeper insight into the evolutionary processes that have shaped this unique human pathogen. In addition, deep sequencing of isolates from a single Coccidioides population and pairing of those data with phenotype information on growth and pathogenicity for genome-wide association analysis will allow researchers to find genes responsible for any phenotype, virulence included, that shows variation in the population.


英文关键词Coccidioides genomics next-generation sequencing evolution dimorphic fungal pathogen
类型Review
语种英语
国家USA
收录类别SCI-E
WOS记录号WOS:000339911800005
WOS关键词POPULATION ; IMMITIS ; REVEALS ; POSADASII ; INCREASE
WOS类目Infectious Diseases ; Mycology ; Veterinary Sciences
WOS研究方向Infectious Diseases ; Mycology ; Veterinary Sciences
来源机构University of California, Berkeley
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/183844
作者单位Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA
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GB/T 7714
Whiston, Emily,Taylor, John W.. Genomics in Coccidioides: Insights into evolution, ecology, and pathogenesis[J]. University of California, Berkeley,2014,52(2):149-155.
APA Whiston, Emily,&Taylor, John W..(2014).Genomics in Coccidioides: Insights into evolution, ecology, and pathogenesis.MEDICAL MYCOLOGY,52(2),149-155.
MLA Whiston, Emily,et al."Genomics in Coccidioides: Insights into evolution, ecology, and pathogenesis".MEDICAL MYCOLOGY 52.2(2014):149-155.
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