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DOI10.1016/j.chroma.2014.04.025
Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals
Al-Qaim, Fouad F.1,2; Abdullah, M. P.1,3; Othman, Mohamed R.1,3; Latip, Jalifah1; Zakaria, Zuriati4
通讯作者Abdullah, M. P.
来源期刊JOURNAL OF CHROMATOGRAPHY A
ISSN0021-9673
EISSN1873-3778
出版年2014
卷号1345页码:139-153
英文摘要

An analytical method that facilitated the analysis of 11 pharmaceuticals residue (caffeine, prazosin, enalapril, carbamazepine, nifedipine, levonorgestrel, simvastatin, hydrochlorothiazide, gliclazide, diclofenac-Na, and mefenamic acid) with a single pre-treatment protocol was developed. The proposed method included an isolation and concentration procedure using solid phase extraction (Oasis HLB), a separation step using high-performance liquid chromatography, and a detection procedure that applies time-of-flight mass spectrometry. The method was validated for drinking water (DW), surface water (SW), sewage treatment plant (STP) influent and effluent, and hospital (HSP) influent and effluent. The limits of quantification were as low as 0.4, 1.6, 5,3, 2.2 and 11 ng/L in DW, SW, HSP influent and effluent, STP effluent, and STP influent, respectively. On average, good recoveries higher than 75% were obtained for most of the target analytes in all matrices. Matrix effect was evaluated for all samples matrices. The proposed method successfully determined and quantified the target compounds in raw and treated wastewater of four STPs and three hospitals in Malaysia, as well as in two SW sites. The results showed that a number of the studied compounds pose moderate to high persistency in sewage treatment effluents as well as in the recipient rivers, namely; caffeine, simvastatin, and hydrochlorothiazide. Ten out of 11 compounds were detected and quantified in 13 sampling points. Caffeine was detected with the highest level, with concentrations reaching up to 9099 ng/L in STP influent. (C) 2014 Elsevier B.V. All rights reserved.


英文关键词Pharmaceuticals Solid phase extraction Effluent and influent of hospital Sewage treatment plants Multi-residue analytical method LC-TOF/MS
类型Article
语种英语
国家Malaysia ; Iraq
收录类别SCI-E
WOS记录号WOS:000336709300016
WOS关键词SOLID-PHASE EXTRACTION ; TRACE-LEVEL DETERMINATION ; WASTE-WATER ; BETA-BLOCKERS ; HUMAN PLASMA ; PRODUCTS ; SAMPLES
WOS类目Biochemical Research Methods ; Chemistry, Analytical
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/183159
作者单位1.UKM, Sch Chem Sci & Food Technol, Fac Sci & Technol, Bangi 43600, Selangor, Malaysia;
2.Babylon Univ, Fac Sci Women, Dept Chem, Hilla, Iraq;
3.UKM, Ctr Water Res & Anal ALIR, Fac Sci & Technol, Bangi 43600, Selangor, Malaysia;
4.Univ Teknol Malaysia, MJIIT, Kuala Lumpur 54100, Malaysia
推荐引用方式
GB/T 7714
Al-Qaim, Fouad F.,Abdullah, M. P.,Othman, Mohamed R.,et al. Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals[J],2014,1345:139-153.
APA Al-Qaim, Fouad F.,Abdullah, M. P.,Othman, Mohamed R.,Latip, Jalifah,&Zakaria, Zuriati.(2014).Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals.JOURNAL OF CHROMATOGRAPHY A,1345,139-153.
MLA Al-Qaim, Fouad F.,et al."Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals".JOURNAL OF CHROMATOGRAPHY A 1345(2014):139-153.
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