Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.chroma.2014.04.025 |
Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals | |
Al-Qaim, Fouad F.1,2; Abdullah, M. P.1,3; Othman, Mohamed R.1,3; Latip, Jalifah1; Zakaria, Zuriati4 | |
通讯作者 | Abdullah, M. P. |
来源期刊 | JOURNAL OF CHROMATOGRAPHY A
![]() |
ISSN | 0021-9673 |
EISSN | 1873-3778 |
出版年 | 2014 |
卷号 | 1345页码:139-153 |
英文摘要 | An analytical method that facilitated the analysis of 11 pharmaceuticals residue (caffeine, prazosin, enalapril, carbamazepine, nifedipine, levonorgestrel, simvastatin, hydrochlorothiazide, gliclazide, diclofenac-Na, and mefenamic acid) with a single pre-treatment protocol was developed. The proposed method included an isolation and concentration procedure using solid phase extraction (Oasis HLB), a separation step using high-performance liquid chromatography, and a detection procedure that applies time-of-flight mass spectrometry. The method was validated for drinking water (DW), surface water (SW), sewage treatment plant (STP) influent and effluent, and hospital (HSP) influent and effluent. The limits of quantification were as low as 0.4, 1.6, 5,3, 2.2 and 11 ng/L in DW, SW, HSP influent and effluent, STP effluent, and STP influent, respectively. On average, good recoveries higher than 75% were obtained for most of the target analytes in all matrices. Matrix effect was evaluated for all samples matrices. The proposed method successfully determined and quantified the target compounds in raw and treated wastewater of four STPs and three hospitals in Malaysia, as well as in two SW sites. The results showed that a number of the studied compounds pose moderate to high persistency in sewage treatment effluents as well as in the recipient rivers, namely; caffeine, simvastatin, and hydrochlorothiazide. Ten out of 11 compounds were detected and quantified in 13 sampling points. Caffeine was detected with the highest level, with concentrations reaching up to 9099 ng/L in STP influent. (C) 2014 Elsevier B.V. All rights reserved. |
英文关键词 | Pharmaceuticals Solid phase extraction Effluent and influent of hospital Sewage treatment plants Multi-residue analytical method LC-TOF/MS |
类型 | Article |
语种 | 英语 |
国家 | Malaysia ; Iraq |
收录类别 | SCI-E |
WOS记录号 | WOS:000336709300016 |
WOS关键词 | SOLID-PHASE EXTRACTION ; TRACE-LEVEL DETERMINATION ; WASTE-WATER ; BETA-BLOCKERS ; HUMAN PLASMA ; PRODUCTS ; SAMPLES |
WOS类目 | Biochemical Research Methods ; Chemistry, Analytical |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/183159 |
作者单位 | 1.UKM, Sch Chem Sci & Food Technol, Fac Sci & Technol, Bangi 43600, Selangor, Malaysia; 2.Babylon Univ, Fac Sci Women, Dept Chem, Hilla, Iraq; 3.UKM, Ctr Water Res & Anal ALIR, Fac Sci & Technol, Bangi 43600, Selangor, Malaysia; 4.Univ Teknol Malaysia, MJIIT, Kuala Lumpur 54100, Malaysia |
推荐引用方式 GB/T 7714 | Al-Qaim, Fouad F.,Abdullah, M. P.,Othman, Mohamed R.,et al. Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals[J],2014,1345:139-153. |
APA | Al-Qaim, Fouad F.,Abdullah, M. P.,Othman, Mohamed R.,Latip, Jalifah,&Zakaria, Zuriati.(2014).Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals.JOURNAL OF CHROMATOGRAPHY A,1345,139-153. |
MLA | Al-Qaim, Fouad F.,et al."Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals".JOURNAL OF CHROMATOGRAPHY A 1345(2014):139-153. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。