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Background: Neurofunctional deficits in chronic depression (CD) have been understudied. Specifically there is no known published study of the effects of a specialized psychotherapy for CD (CBASP) on neurolunctional deficits.

Methods: Ten patients with a DSM-IV diagnosis of CD received a 12 week specialised psychotherapy (CBASP). Controls were healthy matched volunteers. All subjects participated in a prospective study with functional magnetic resonance imaging (1MR1) at baseline and after 12 weeks. During the IMRI scans, subjects performed an implicit arid explicit emotional processing task while vvaLching dynamic displays of neutral, positive (happy) and negative (fearful and sad) facial expressions. Effects of treatment vvere analyzed in a repeated measures design. The analysis was restricted to Lvvo anatomically defined regions of interest (ROI): the amygdala and the cingulum.

Results: 60% of patients responded to treatment. Patients with CD reported increased arousal to negative emotional expressions. They also shovvecl an increase in left amygclala reactivity during implicit processing of emotional expressions following psychotherapy. We found no significant effect for the cingulum.

Limitations: The main limitation of our study is the small sample size. Due to the lack of a control group it is also unclear whether the demonstrated effect is specific to the psychotherapy used in this study.

Conclusions: For the first time our study demonstrates an effect of CBASP On neural processing of facial emotions in CD. It therefore adds to the growing evidence supporting this treatment. (C) 2014 Elsevier B.V. All rights reserved