Arid
DOI10.1016/j.humimm.2014.09.009
The Raikas - A unique combination of high prevalence of type 1 diabetes susceptibility genes and near zero incidence of the disease
Bhat, Deepali K.1; Kanga, Uma1; Kumar, Neeraj1; Agrawal, R. P.2; Mourya, Manish1; Kalaivani, Mani3; Kaur, Tanvir4; Mehra, Narinder K.1
通讯作者Kanga, Uma
来源期刊HUMAN IMMUNOLOGY
ISSN0198-8859
EISSN1879-1166
出版年2014
卷号75期号:12页码:1252-1258
英文摘要

The Raikas, a camel rearing tribal group living in the Thar desert of Rajasthan has been reported with a very low incidence of diabetes. We analysed the frequency distribution of HLA alleles in this community and compared the same with the non-Raika group living in the same geographic location and also that of the healthy North Indian (NI) population. The data revealed an exceptionally high phenotype frequency of HLA-DRB1*03 in this community (53%) as compared to the non-Raika group (27.73%, p = 7.9E-05) and the NI population (14.6%, p = 7.65E06). Further analysis revealed the occurrence of four major DRB1*03 haplotypes in the Raikas: (i) A*26-B*08-DRB1*03 (AH8.2, 11.76%); (ii) A*24-B*08-DRB1*03 (AH8.3, 8.82%); (iii) A*02-B*08-DRB1*03 (3.78%); (iv) A*01-B*08-DRB1*03 (AH8.1v, 0.84%); all of which occurred with a several fold higher frequency in the Raikas than the other two groups. These haplotypes have been reported to be positively associated with T1D in the NI population. The apparent lack of T1D and/or other autoimmune diseases in the Raikas despite the higher occurrence of known disease associated HLA alleles/haplotypes is intriguing and highlights the quintessential role of the environmental factors, food habits and level of physical activity in the manifestation of T1D. Possible influence of other protection conferring genes located on, as yet undefined chromosomal locations cannot be ruled out. (C) 2014 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.


英文关键词Raika community Camel milk Type1 diabetes HLA Haplotypes
类型Article
语种英语
国家India
收录类别SCI-E
WOS记录号WOS:000346041100018
WOS关键词RANDOMIZED CONTROLLED-TRIAL ; 8.1 ANCESTRAL HAPLOTYPE ; CAMEL MILK ; ENTEROVIRUS INFECTION ; ENVIRONMENTAL-FACTORS ; ALLERGIC DISEASES ; JAPANESE CHILDREN ; GLYCEMIC CONTROL ; IMMUNE-RESPONSE ; CLASS-I
WOS类目Immunology
WOS研究方向Immunology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/182425
作者单位1.All India Inst Med Sci, Dept Transplant Immunol & Immunogenet, New Delhi 110029, India;
2.SP Med Coll, Dept Med, Bikaner, Rajasthan, India;
3.All India Inst Med Sci, Dept Biostat, New Delhi 110029, India;
4.Indian Council Med Res, New Delhi, India
推荐引用方式
GB/T 7714
Bhat, Deepali K.,Kanga, Uma,Kumar, Neeraj,et al. The Raikas - A unique combination of high prevalence of type 1 diabetes susceptibility genes and near zero incidence of the disease[J],2014,75(12):1252-1258.
APA Bhat, Deepali K..,Kanga, Uma.,Kumar, Neeraj.,Agrawal, R. P..,Mourya, Manish.,...&Mehra, Narinder K..(2014).The Raikas - A unique combination of high prevalence of type 1 diabetes susceptibility genes and near zero incidence of the disease.HUMAN IMMUNOLOGY,75(12),1252-1258.
MLA Bhat, Deepali K.,et al."The Raikas - A unique combination of high prevalence of type 1 diabetes susceptibility genes and near zero incidence of the disease".HUMAN IMMUNOLOGY 75.12(2014):1252-1258.
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