Arid
DOI10.1155/2014/862307
An Ensemble-of-Classifiers Based Approach for Early Diagnosis of Alzheimer’s Disease: Classification Using Structural Features of Brain Images
Farhan, Saima; Fahiem, Muhammad Abuzar; Tauseef, Huma
通讯作者Fahiem, Muhammad Abuzar
来源期刊COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
ISSN1748-670X
EISSN1748-6718
出版年2014
英文摘要

Structural brain imaging is playing a vital role in identification of changes that occur in brain associated with Alzheimer’s disease. This paper proposes an automated image processing based approach for the identification of AD from MRI of the brain. The proposed approach is novel in a sense that it has higher specificity/accuracy values despite the use of smaller feature set as compared to existing approaches. Moreover, the proposed approach is capable of identifying AD patients in early stages. The dataset selected consists of 85 age and gender matched individuals from OASIS database. The features selected are volume of GM, WM, and CSF and size of hippocampus. Three different classification models (SVM, MLP, and J48) are used for identification of patients and controls. In addition, an ensemble of classifiers, based on majority voting, is adopted to overcome the error caused by an independent base classifier. Ten-fold cross validation strategy is applied for the evaluation of our scheme. Moreover, to evaluate the performance of proposed approach, individual features and combination of features are fed to individual classifiers and ensemble based classifier. Using size of left hippocampus as feature, the accuracy achieved with ensemble of classifiers is 93.75%, with 100% specificity and 87.5% sensitivity.


类型Article
语种英语
国家Pakistan
收录类别SCI-E
WOS记录号WOS:000344319400001
WOS关键词MILD COGNITIVE IMPAIRMENT ; PATTERN-CLASSIFICATION ; FEATURE-SELECTION ; MR-IMAGES ; ATROPHY ; PREDICTION ; IMPACT
WOS类目Mathematical & Computational Biology
WOS研究方向Mathematical & Computational Biology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/181455
作者单位Lahore Coll Women Univ, Dept Comp Sci, Lahore 54000, Pakistan
推荐引用方式
GB/T 7714
Farhan, Saima,Fahiem, Muhammad Abuzar,Tauseef, Huma. An Ensemble-of-Classifiers Based Approach for Early Diagnosis of Alzheimer’s Disease: Classification Using Structural Features of Brain Images[J],2014.
APA Farhan, Saima,Fahiem, Muhammad Abuzar,&Tauseef, Huma.(2014).An Ensemble-of-Classifiers Based Approach for Early Diagnosis of Alzheimer’s Disease: Classification Using Structural Features of Brain Images.COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE.
MLA Farhan, Saima,et al."An Ensemble-of-Classifiers Based Approach for Early Diagnosis of Alzheimer’s Disease: Classification Using Structural Features of Brain Images".COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE (2014).
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