Arid
DOI10.1016/j.carbpol.2013.09.005
Exopolymers from Tolypothrix tenuis and three Anabaena sp (Cyanobacteriaceae) as novel blood clotting agents for wound management
Bhatnagar, Monica1; Parwani, Laxmi2; Sharma, Vinay2; Ganguly, Jhuma3; Bhatnagar, Ashish1
通讯作者Bhatnagar, Monica
来源期刊CARBOHYDRATE POLYMERS
ISSN0144-8617
EISSN1879-1344
出版年2014
卷号99页码:692-699
英文摘要

Rapid initiation of clotting is critical to trauma patients. In the present study exopolymers (EPs) from four desert cyanobacteria including Tolypothrix tenuis and three species of Anabaena have been discovered as potential hemostatic biomaterials. The EPs showed reduction in activated partial thromboplastin time (APTT) and prothrombin time (PT) by 16-41% and 12-65%, respectively. Besides hastening blood clotting, the EPs could absorb 7.1-25.9 g H2O g(-1) EP and displayed 7.1-18.1% hydrophobicity. They were noncytotoxic and biodegradable. The EP from Anabaena sp. showed strong antibacterial activity against E. coli, S. aureus and B. licheniformis. These results suggest that cyanobacteria, the microscopic phototrophs growing rapidly over simple mineral medium could prove to be a novel source of affordable hemostatic dressings for the traumatic wounds in underdeveloped and developing countries. Compositional analysis of the EPs showed them to be consisting of mainly carbohydrate (17-50%), protein (4.4-7.2%), uronic acid (4.7-9.5%) and sulphate (0.6-6.6%). Their viscometric molecular weight ranged from 539 to 3679 kDa. They were further characterized using GC-MS and FTIR. (C) 2013 Elsevier Ltd. All rights reserved.


英文关键词Antibacterial Biodegradable Cyanobacteria Cytotoxicity Exopolymers Thrombogenic Wound healing
类型Article
语种英语
国家India
收录类别SCI-E
WOS记录号WOS:000329256600088
WOS关键词PLATELET-ADHESION ; MOLECULAR-WEIGHT ; CHITOSAN ; POLYSACCHARIDE ; CYTOTOXICITY ; INJURY ; ACID
WOS类目Chemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS研究方向Chemistry ; Polymer Science
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/181272
作者单位1.MDS Univ, Dept Microbiol, Algae Biofuel & Biomol Ctr, Ajmer 305009, Rajasthan, India;
2.Banasthali Vidyapith, Dept Biosci & Biotechnol, Vidyapith, Rajasthan, India;
3.Bengal Engn & Sci Univ, Dept Chem, Howrah 711103, W Bengal, India
推荐引用方式
GB/T 7714
Bhatnagar, Monica,Parwani, Laxmi,Sharma, Vinay,et al. Exopolymers from Tolypothrix tenuis and three Anabaena sp (Cyanobacteriaceae) as novel blood clotting agents for wound management[J],2014,99:692-699.
APA Bhatnagar, Monica,Parwani, Laxmi,Sharma, Vinay,Ganguly, Jhuma,&Bhatnagar, Ashish.(2014).Exopolymers from Tolypothrix tenuis and three Anabaena sp (Cyanobacteriaceae) as novel blood clotting agents for wound management.CARBOHYDRATE POLYMERS,99,692-699.
MLA Bhatnagar, Monica,et al."Exopolymers from Tolypothrix tenuis and three Anabaena sp (Cyanobacteriaceae) as novel blood clotting agents for wound management".CARBOHYDRATE POLYMERS 99(2014):692-699.
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