Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.carbpol.2013.09.005 |
Exopolymers from Tolypothrix tenuis and three Anabaena sp (Cyanobacteriaceae) as novel blood clotting agents for wound management | |
Bhatnagar, Monica1; Parwani, Laxmi2; Sharma, Vinay2; Ganguly, Jhuma3; Bhatnagar, Ashish1 | |
通讯作者 | Bhatnagar, Monica |
来源期刊 | CARBOHYDRATE POLYMERS
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ISSN | 0144-8617 |
EISSN | 1879-1344 |
出版年 | 2014 |
卷号 | 99页码:692-699 |
英文摘要 | Rapid initiation of clotting is critical to trauma patients. In the present study exopolymers (EPs) from four desert cyanobacteria including Tolypothrix tenuis and three species of Anabaena have been discovered as potential hemostatic biomaterials. The EPs showed reduction in activated partial thromboplastin time (APTT) and prothrombin time (PT) by 16-41% and 12-65%, respectively. Besides hastening blood clotting, the EPs could absorb 7.1-25.9 g H2O g(-1) EP and displayed 7.1-18.1% hydrophobicity. They were noncytotoxic and biodegradable. The EP from Anabaena sp. showed strong antibacterial activity against E. coli, S. aureus and B. licheniformis. These results suggest that cyanobacteria, the microscopic phototrophs growing rapidly over simple mineral medium could prove to be a novel source of affordable hemostatic dressings for the traumatic wounds in underdeveloped and developing countries. Compositional analysis of the EPs showed them to be consisting of mainly carbohydrate (17-50%), protein (4.4-7.2%), uronic acid (4.7-9.5%) and sulphate (0.6-6.6%). Their viscometric molecular weight ranged from 539 to 3679 kDa. They were further characterized using GC-MS and FTIR. (C) 2013 Elsevier Ltd. All rights reserved. |
英文关键词 | Antibacterial Biodegradable Cyanobacteria Cytotoxicity Exopolymers Thrombogenic Wound healing |
类型 | Article |
语种 | 英语 |
国家 | India |
收录类别 | SCI-E |
WOS记录号 | WOS:000329256600088 |
WOS关键词 | PLATELET-ADHESION ; MOLECULAR-WEIGHT ; CHITOSAN ; POLYSACCHARIDE ; CYTOTOXICITY ; INJURY ; ACID |
WOS类目 | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
WOS研究方向 | Chemistry ; Polymer Science |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/181272 |
作者单位 | 1.MDS Univ, Dept Microbiol, Algae Biofuel & Biomol Ctr, Ajmer 305009, Rajasthan, India; 2.Banasthali Vidyapith, Dept Biosci & Biotechnol, Vidyapith, Rajasthan, India; 3.Bengal Engn & Sci Univ, Dept Chem, Howrah 711103, W Bengal, India |
推荐引用方式 GB/T 7714 | Bhatnagar, Monica,Parwani, Laxmi,Sharma, Vinay,et al. Exopolymers from Tolypothrix tenuis and three Anabaena sp (Cyanobacteriaceae) as novel blood clotting agents for wound management[J],2014,99:692-699. |
APA | Bhatnagar, Monica,Parwani, Laxmi,Sharma, Vinay,Ganguly, Jhuma,&Bhatnagar, Ashish.(2014).Exopolymers from Tolypothrix tenuis and three Anabaena sp (Cyanobacteriaceae) as novel blood clotting agents for wound management.CARBOHYDRATE POLYMERS,99,692-699. |
MLA | Bhatnagar, Monica,et al."Exopolymers from Tolypothrix tenuis and three Anabaena sp (Cyanobacteriaceae) as novel blood clotting agents for wound management".CARBOHYDRATE POLYMERS 99(2014):692-699. |
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