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DOI10.1016/j.bmc.2014.08.039
Altertoxins with potent anti-HIV activity from Alternaria tenuissima QUE1Se, a fungal endophyte of Quercus emoryi
Bashyal, Bharat P.1; Wellensiek, Brian P.2,4; Ramakrishnan, Rajesh2; Faeth, Stanley H.3,5; Ahmad, Nafees2; Gunatilaka, A. A. Leslie1
通讯作者Gunatilaka, A. A. Leslie
来源期刊BIOORGANIC & MEDICINAL CHEMISTRY
ISSN0968-0896
EISSN1464-3391
出版年2014
卷号22期号:21页码:6112-6116
英文摘要

Screening of a small library of natural product extracts derived from endophytic fungi of the Sonoran desert plants in a cell-based anti-HIV assay involving T-cells infected with the HIV-1 virus identified the EtOAc extract of a fermentation broth of Alternaria tenuissima QUE1Se inhabiting the stem tissue of Quercus emoryi as a promising candidate for further investigation. Bioactivity-guided fractionation of this extract led to the isolation and identification of two new metabolites, altertoxins V (1) and VI (2) together with the known compounds, altertoxins I (3), II (4), and III (5). The structures of 1 and 2 were determined by detailed spectroscopic analysis and those of 3-5 were established by comparison with reported data. When tested in our cell-based assay at concentrations insignificantly toxic to T-cells, altertoxins V (1), I (3), II (4), and III (5) completely inhibited replication of the HIV-1 virus at concentrations of 0.50, 2.20, 0.30, and 1.50 mu M, respectively. Our findings suggest that the epoxyperylene structural scaffold in altertoxins may be manipulated to produce potent anti-HIV therapeutics. (C) 2014 Elsevier Ltd. All rights reserved.


英文关键词Alternaria tenuissima Endophytic fungus Anti-HIV activity Altertoxin V Altertoxin VI
类型Article
语种英语
国家USA
收录类别SCI-E
WOS记录号WOS:000344471800039
WOS关键词PERYLENEQUINONE METABOLITES ; A-E ; PROTEASE ; PHYTOTOXINS ; CELLS
WOS类目Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
来源机构University of Arizona ; Arizona State University
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/181136
作者单位1.Univ Arizona, Southwest Ctr Nat Prod Res, Sch Nat Resources & Environm, Coll Agr & Life Sci, Tucson, AZ 85706 USA;
2.Univ Arizona, Dept Immunobiol, Coll Med, Tucson, AZ 85724 USA;
3.Arizona State Univ, Coll Liberal Arts & Sci, Sch Life Sci, Tempe, AZ 85287 USA;
4.Midwestern Univ, Coll Hlth Sci, Program Biomed Sci, Glendale, AZ 85308 USA;
5.Univ N Carolina, Dept Biol, Greensboro, NC 27402 USA
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Bashyal, Bharat P.,Wellensiek, Brian P.,Ramakrishnan, Rajesh,et al. Altertoxins with potent anti-HIV activity from Alternaria tenuissima QUE1Se, a fungal endophyte of Quercus emoryi[J]. University of Arizona, Arizona State University,2014,22(21):6112-6116.
APA Bashyal, Bharat P.,Wellensiek, Brian P.,Ramakrishnan, Rajesh,Faeth, Stanley H.,Ahmad, Nafees,&Gunatilaka, A. A. Leslie.(2014).Altertoxins with potent anti-HIV activity from Alternaria tenuissima QUE1Se, a fungal endophyte of Quercus emoryi.BIOORGANIC & MEDICINAL CHEMISTRY,22(21),6112-6116.
MLA Bashyal, Bharat P.,et al."Altertoxins with potent anti-HIV activity from Alternaria tenuissima QUE1Se, a fungal endophyte of Quercus emoryi".BIOORGANIC & MEDICINAL CHEMISTRY 22.21(2014):6112-6116.
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