Arid
DOI10.1080/09291016.2013.869438
Thermal dependency of electrical excitability of gastrocnemius (skeletal) muscle in the desert-reptile, Uromastix hardwickii
Soomro, Mohammad Saleh1; Mahar, Saeed Ahmed2; Qureshi, Aijaz Ahmed3; Soomro, Mohammad Naeem4; Soomro, Mohammad Waseem5
通讯作者Soomro, Mohammad Saleh
来源期刊BIOLOGICAL RHYTHM RESEARCH
ISSN0929-1016
EISSN1744-4179
出版年2014
卷号45期号:4页码:515-522
英文摘要

This study deals with effects of seasonal temperature variations on muscular electrical excitability in the reptile Uromastix hardwickii. Freshly captured adult animals of both sexes were used, and the gastrocnemius (skeletal) muscles were dissected out. The muscle samples were digested with digestive fluid (pepsin and HCl), stirred, and the cells were allowed to settle out. The supernatant was removed leaving a whitish fluid containing clear cells that were used for "patch-clamp" recording of membrane ionic currents and potentials. Resting membrane potentials (RMPs) and action potentials of the cell membranes were measured using the whole-cell current mode. Glass microelectrodes, with a tip diameter 2-3 mu m and tip resistance 5-6 MO (when filled with intracellular solution), were used. The mean values for RMP action potential and its duration showed no significant changes with the season, but other components of action potential, including threshold potential, after-potential, and its duration, were found to increase significantly (p < 0.05) in summer as compared to winter. This is the first study of seasonal temperature dependency of these parameters in the gastrocnemius muscle of U. hardwickii. This study shows that seasonal changes in components of the action potential are associated with changes in environmental temperature. These changes may be responsible for altered activities and homeostasis in these animals, and possibly related to the underlying mechanisms responsible for hibernation.


英文关键词Uromastix hardwickii gastrocnemius muscle environmental temperature patch-clamp technique phases of action potential
类型Article
语种英语
国家Pakistan
收录类别SCI-E
WOS记录号WOS:000337580100003
WOS关键词PATCH-CLAMP ; TISSUE ; GANGLION ; CURRENTS ; NEURONS
WOS类目Biology ; Physiology
WOS研究方向Life Sciences & Biomedicine - Other Topics ; Physiology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/181110
作者单位1.Liaquat Natl Med Coll, Dept Physiol, Karachi, Pakistan;
2.Liaquat Natl Hosp & Med Coll, Dept Med, Karachi, Pakistan;
3.Sindh Med Univ, Dept Physiol, Karachi, Pakistan;
4.NED Univ, Civil Dept, Karachi, Pakistan;
5.NED Univ, Dept Mech, Karachi, Pakistan
推荐引用方式
GB/T 7714
Soomro, Mohammad Saleh,Mahar, Saeed Ahmed,Qureshi, Aijaz Ahmed,et al. Thermal dependency of electrical excitability of gastrocnemius (skeletal) muscle in the desert-reptile, Uromastix hardwickii[J],2014,45(4):515-522.
APA Soomro, Mohammad Saleh,Mahar, Saeed Ahmed,Qureshi, Aijaz Ahmed,Soomro, Mohammad Naeem,&Soomro, Mohammad Waseem.(2014).Thermal dependency of electrical excitability of gastrocnemius (skeletal) muscle in the desert-reptile, Uromastix hardwickii.BIOLOGICAL RHYTHM RESEARCH,45(4),515-522.
MLA Soomro, Mohammad Saleh,et al."Thermal dependency of electrical excitability of gastrocnemius (skeletal) muscle in the desert-reptile, Uromastix hardwickii".BIOLOGICAL RHYTHM RESEARCH 45.4(2014):515-522.
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