Arid
DOI10.1684/abc.2014.0944
Analytical validation of a chromatographic method dedicated to search and identify natural and semi-synthetic opiates
Dubois, Nathalie1; Counerotte, Stephane2; Goffin, Eric2; Pirotte, Bernard2,3; Charlier, Corinne1,3
通讯作者Dubois, Nathalie
来源期刊ANNALES DE BIOLOGIE CLINIQUE
ISSN0003-3898
EISSN1950-6112
出版年2014
卷号72期号:2页码:197-206
英文摘要

The identification of a product absorbed by an opiate consumer is sometimes problematic since there is no specific biomarker for all molecules. We developed an ultra-high pressure liquid chromatography coupled to tandem mass spectrometry technique which allows the identification and the quantification of 25 opiates in plasma. The sample preparation consists in a solid-phase extraction on Oasis (R) MCX cartridges (Waters). The method has been validated according to FDA criteria completely for 21 substances and with some reservations for the remaining 4 analytes. This method has been applied to 80 patients treated at the University Hospital of Liege for whom the screening of opiates was positive. The identification of the product consumed was effective in 86% of cases.


英文关键词analytical validation opiates identification plasma LC-MS
类型Article
语种French
国家Belgium
收录类别SCI-E
WOS记录号WOS:000334820600007
WOS关键词ILLICIT HEROIN USE ; FEMORAL BLOOD ; METABOLITES ; MORPHINE ; CODEINE ; DEATHS ; MARKER
WOS类目Medical Laboratory Technology ; Medicine, Research & Experimental
WOS研究方向Medical Laboratory Technology ; Research & Experimental Medicine
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/180655
作者单位1.CHU, Serv Toxicol Clin Med Legale Environm & Enterpr, Liege, Belgium;
2.Univ Liege, Dept Pharm, Serv Chim Pharmaceut, B-4000 Liege, Belgium;
3.Univ Liege, CIRM, B-4000 Liege, Belgium
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GB/T 7714
Dubois, Nathalie,Counerotte, Stephane,Goffin, Eric,et al. Analytical validation of a chromatographic method dedicated to search and identify natural and semi-synthetic opiates[J],2014,72(2):197-206.
APA Dubois, Nathalie,Counerotte, Stephane,Goffin, Eric,Pirotte, Bernard,&Charlier, Corinne.(2014).Analytical validation of a chromatographic method dedicated to search and identify natural and semi-synthetic opiates.ANNALES DE BIOLOGIE CLINIQUE,72(2),197-206.
MLA Dubois, Nathalie,et al."Analytical validation of a chromatographic method dedicated to search and identify natural and semi-synthetic opiates".ANNALES DE BIOLOGIE CLINIQUE 72.2(2014):197-206.
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