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DOI | 10.1684/abc.2014.0944 |
Analytical validation of a chromatographic method dedicated to search and identify natural and semi-synthetic opiates | |
Dubois, Nathalie1; Counerotte, Stephane2; Goffin, Eric2; Pirotte, Bernard2,3; Charlier, Corinne1,3 | |
通讯作者 | Dubois, Nathalie |
来源期刊 | ANNALES DE BIOLOGIE CLINIQUE
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ISSN | 0003-3898 |
EISSN | 1950-6112 |
出版年 | 2014 |
卷号 | 72期号:2页码:197-206 |
英文摘要 | The identification of a product absorbed by an opiate consumer is sometimes problematic since there is no specific biomarker for all molecules. We developed an ultra-high pressure liquid chromatography coupled to tandem mass spectrometry technique which allows the identification and the quantification of 25 opiates in plasma. The sample preparation consists in a solid-phase extraction on Oasis (R) MCX cartridges (Waters). The method has been validated according to FDA criteria completely for 21 substances and with some reservations for the remaining 4 analytes. This method has been applied to 80 patients treated at the University Hospital of Liege for whom the screening of opiates was positive. The identification of the product consumed was effective in 86% of cases. |
英文关键词 | analytical validation opiates identification plasma LC-MS |
类型 | Article |
语种 | French |
国家 | Belgium |
收录类别 | SCI-E |
WOS记录号 | WOS:000334820600007 |
WOS关键词 | ILLICIT HEROIN USE ; FEMORAL BLOOD ; METABOLITES ; MORPHINE ; CODEINE ; DEATHS ; MARKER |
WOS类目 | Medical Laboratory Technology ; Medicine, Research & Experimental |
WOS研究方向 | Medical Laboratory Technology ; Research & Experimental Medicine |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/180655 |
作者单位 | 1.CHU, Serv Toxicol Clin Med Legale Environm & Enterpr, Liege, Belgium; 2.Univ Liege, Dept Pharm, Serv Chim Pharmaceut, B-4000 Liege, Belgium; 3.Univ Liege, CIRM, B-4000 Liege, Belgium |
推荐引用方式 GB/T 7714 | Dubois, Nathalie,Counerotte, Stephane,Goffin, Eric,et al. Analytical validation of a chromatographic method dedicated to search and identify natural and semi-synthetic opiates[J],2014,72(2):197-206. |
APA | Dubois, Nathalie,Counerotte, Stephane,Goffin, Eric,Pirotte, Bernard,&Charlier, Corinne.(2014).Analytical validation of a chromatographic method dedicated to search and identify natural and semi-synthetic opiates.ANNALES DE BIOLOGIE CLINIQUE,72(2),197-206. |
MLA | Dubois, Nathalie,et al."Analytical validation of a chromatographic method dedicated to search and identify natural and semi-synthetic opiates".ANNALES DE BIOLOGIE CLINIQUE 72.2(2014):197-206. |
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