Arid
DOI10.1021/nn405398d
A Light-Responsive Release Platform by Controlling the Wetting Behavior of Hydrophobic Surface
Chen, Linfeng1,2; Wang, Wenqian3; Su, Bin1; Wen, Yongqiang3; Li, Chuanbao3; Zhou, Yabin3; Li, Mingzhu1; Shi, Xiaodi1,2; Du, Hongwu3; Song, Yanlin1; Jiang, Lei1
通讯作者Wen, Yongqiang
来源期刊ACS NANO
ISSN1936-0851
EISSN1936-086X
出版年2014
卷号8期号:1页码:744-751
英文摘要

Controlled release system based on mesoporous silica (MS) nanomaterials has drawn great attention over the past decades due to its potential biomedical applications. Herein, a light responsive release system based on MS nanoparticles was achieved by adjusting the wetting of the MS surface. At the starting stage, the surface of MS modified with optimal ratio of spiropyran to fluorinated silane (MS-FSP) was protected from being wetted by water, successfully inhibiting the release of model cargo molecules, fluorescein disodium (FD). Upon irradiation with 365 nm UV light, the conformational conversion of spiropyran from a "closed" state to an "open" state caused the surface to be wetted, leading to the release of FD from the pores. The further in vitro studies demonstrated the system loaded with anticancer drug camptothecin (CPT) could be effectively controlled to release the drug by UV light stimuli to enhance cytotoxicity for EA.hy926 cells and He La cells. This wettability-determined smart release platform could be triggered by remote stimuli, which might hold promise in the applications of drug delivery and cancer therapy.


英文关键词mesoporous silica spiropyran light-responsive controlled release wetting
类型Article
语种英语
国家Peoples R China
收录类别SCI-E
WOS记录号WOS:000330542900076
WOS关键词MESOPOROUS SILICA NANOPARTICLES ; DRUG-DELIVERY ; PHOTOCHROMIC SPIROPYRAN ; CARRIER SYSTEM ; DESERT BEETLE ; WATER ; SEPARATION ; MOLECULES ; SPHERES ; MESH
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/180332
作者单位1.Chinese Acad Sci, Key Lab Green Printing, Key Lab Organ Solids, BNLMS,Inst Chem, Beijing 100190, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
3.Univ Sci & Technol Beijing, Res Ctr Bioengn & Sensing Technol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Chen, Linfeng,Wang, Wenqian,Su, Bin,et al. A Light-Responsive Release Platform by Controlling the Wetting Behavior of Hydrophobic Surface[J],2014,8(1):744-751.
APA Chen, Linfeng.,Wang, Wenqian.,Su, Bin.,Wen, Yongqiang.,Li, Chuanbao.,...&Jiang, Lei.(2014).A Light-Responsive Release Platform by Controlling the Wetting Behavior of Hydrophobic Surface.ACS NANO,8(1),744-751.
MLA Chen, Linfeng,et al."A Light-Responsive Release Platform by Controlling the Wetting Behavior of Hydrophobic Surface".ACS NANO 8.1(2014):744-751.
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