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High-resolution gamma ray spectrometry was exploited to locate the potential radioactive targets at Kab Amiri granite pluton, Central Eastern Desert, Egypt. The Kab Amiri pluton forms a concentric granitic body of monzogranite to syenogranite composition intruded into mafic-ultramific rocks. To identify and detect anomalous concentrations of natural radioactive elements in the study area, contour maps of equivalent uranium (eU ppm), equivalent thorium (eTh ppm), potassium (K%) and their geochemical ratios (eU/Th, eTh/K and eU-eTh/3.5) as well as standard deviation map of uranium were constructed and interpreted. Qualitative and quantitative interpretations of the spectrometric survey data revealed the presence of seven radioactive anomalies in the south of the studied area. These anomalies could be related to the prevailing faulting directions NE and ENE fault trends. The southernmost anomalous zone is related to high episyenitization and uranium concentrations. It exhibits a sharp increase in the eU concentrations reaching 370 ppm resulting in a high eU/eTh ratio reaching 4.5 and characterized by oval shape trending in the NE direction. Constructing the contour map of the (eU-eTh/3.5) was helpful in defining the trends of uranium migration and enabling the delineation of the limit between the negative contours (leaching) and positive contours (deposition).