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A palaeolimnological study of Lake Khali was undertaken to reconstruct impacts from five thousand years of climate change and human activity in the Ol’khon region of Lake Baikal. Taiga biome dominated regional landscapes, although significant compositional turnover occurred due to the expansion of eurythermic and drought resistant Scots pine. Climate during the mid-Holocene was wetter than the present, and Lake Khali was fresh, with abundant molluscs. By 4.4 cal ka BP, sedimentary geochemistry indicated a gradual change in lake water chemistry with an increase in lake salinity up to the present day, most likely controlled by groundwater influences. Vegetation turnover rate was highest between 2.75 and 2.48 cal ka BP, with the onset of drier, more continental climate, which resulted in an influx of aeolian particles to the lake. This abrupt shift was coincident with ice rafted debris event (IRD-2) in North Atlantic sediments and an attenuation of the East Asian summer monsoon. A second arid period occurred shortly afterwards (2.12-1.87 cal ka BP) which resulted in the decline in ostracod numbers, especially Candona sp. A rather more quiescent, warmer period followed, between 1.9 and 0.7 cal ka BP, with very little change in vegetation composition, and low amounts of detrital transfer from catchment to the lake. Peak reconstructed temperatures (and low amounts of annual precipitation) were concurrent with the Medieval Climate Anomaly. Between 0.77 and 0.45 cal ka BP, climate in the Ol’khon region became colder and wetter, although Lake Khali did not become fresher. Cold, wet conditions are seen at other sites around Lake Baikal, and therefore represent a regional response to the period concurrent with the Little Ice Age and IRD-0. After AD 1845 the region warms, and Pediastrum appears in the lake in high abundances for the first time. This increase is ascribed to nutrient enrichment in the lake, linked to the rapid increase in regional pastoral farming. (c) 2012 Elsevier Ltd and INQUA. All rights reserved.