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Common Variants at 8q24 Confer Susceptibility to Urothelial Bladder Cancer in the Pakistani Population
Ali, Syeda Hafiza Benish1; Younis, Muhammad2,3; Bangash, Kashif Sardar4; Rauf, Abdur5; Anwar, Khursheed4; Khurram, Raja1; Khawaja, Muhammad Athar6; Qureshi, Abid Ali7,8; Akhter, Saeed6; Azam, Maleeha1; Kiemeney, Lambertus A.9,10; Qamar, Raheel1,11
通讯作者Qamar, Raheel
来源期刊PAKISTAN JOURNAL OF ZOOLOGY
ISSN0030-9923
出版年2013
卷号45期号:6页码:1501-1509
英文摘要

8q24 has recently received much attention after genome-wide studies identified the association of common sequence variants in the 8q24.21 gene desert as well as a 5’UTR polymorphism of the PSCA gene with individual susceptibility to urinary bladder cancer (UBC). The objective of the present study was to determine the association of selected single nucleotide polymorphisms (SNPs) at the 8q24 locus (rs9642880 and rs6983267 at 8q24.21 and rs2294008 near the prostate stem cell antigen [PSCA]) with urothelial bladder cancer (UBC) among the Pakistani population. For this purpose, genotyping of selected SNPs was performed by simple allele-discriminating polymerase chain reaction (PCR) in 200 UBC cases and 200 healthy controls. All three variants were found to be associated with a significantly increased UBC risk (p<0.05) after adjusting for age, gender and smoking. rs9642880 was found to be associated slightly stronger with low grade as compared to high grade UBC, while rs2294008 was associated with increased risk of high grade and invasive stages of the disease, and rs6983267 exhibited a strong positive association with UBC risk irrespective of tumor stage and grade. In conclusion, the current study shows a significant involvement of the 8q24 locus in UBC etiology in Pakistani patients.


英文关键词Urothelial bladder cancer 8q24 locus genotyping single nucleotide polymorphism
类型Article
语种英语
国家Pakistan ; Netherlands
收录类别SCI-E
WOS记录号WOS:000330012300004
WOS关键词STEM-CELL ANTIGEN ; IN-SITU HYBRIDIZATION ; PROSTATE-CANCER ; URINARY-BLADDER ; GENETIC-VARIATION ; CHINESE POPULATION ; PSCA ; RISK ; CHROMOSOME ; EXPRESSION
WOS类目Zoology
WOS研究方向Zoology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/179129
作者单位1.COMSATS Inst Informat Technol, Dept Biosci, Fac Sci, Islamabad 45600, Pakistan;
2.King Edward Med Univ, Lahore 54000, Pakistan;
3.Mayo Hosp, Dept Urol, Lahore 54000, Pakistan;
4.Pakistan Atom Energy Commiss Gen Hosp, Islamabad 44000, Pakistan;
5.Nishtar Med Coll & Hosp, Multan 60000, Pakistan;
6.Shifa Int Hosp, Dept Urol, Islamabad 44000, Pakistan;
7.Childrens Hosp, Dept Radiol, Lahore 54000, Pakistan;
8.Inst Child Hlth, Lahore 54000, Pakistan;
9.Radboud Univ Nijmegen Med Ctr, Dept Hlth Evidence, NL-6500 HB Nijmegen, Netherlands;
10.Radboud Univ Nijmegen Med Ctr, Dept Urol, NL-6500 HB Nijmegen, Netherlands;
11.Isra Univ, Al Nafees Med Coll & Hosp, Islamabad, Pakistan
推荐引用方式
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Ali, Syeda Hafiza Benish,Younis, Muhammad,Bangash, Kashif Sardar,et al. Common Variants at 8q24 Confer Susceptibility to Urothelial Bladder Cancer in the Pakistani Population[J],2013,45(6):1501-1509.
APA Ali, Syeda Hafiza Benish.,Younis, Muhammad.,Bangash, Kashif Sardar.,Rauf, Abdur.,Anwar, Khursheed.,...&Qamar, Raheel.(2013).Common Variants at 8q24 Confer Susceptibility to Urothelial Bladder Cancer in the Pakistani Population.PAKISTAN JOURNAL OF ZOOLOGY,45(6),1501-1509.
MLA Ali, Syeda Hafiza Benish,et al."Common Variants at 8q24 Confer Susceptibility to Urothelial Bladder Cancer in the Pakistani Population".PAKISTAN JOURNAL OF ZOOLOGY 45.6(2013):1501-1509.
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