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| DOI | 10.1038/ng.2645 |
| Genome-wide association study identifies two susceptibility loci for osteosarcoma | |
| Savage, Sharon A.1; Mirabello, Lisa1; Wang, Zhaoming2; Gastier-Foster, Julie M.3,4; Gorlick, Richard5; Khanna, Chand6; Flanagan, Adrienne M.7,8; Tirabosco, Roberto8; Andrulis, Irene L.9; Wunder, Jay S.9; Gokgoz, Nalan9; Patino-Garcia, Ana10; Sierrasesumaga, Luis10; Lecanda, Fernando10; Kurucu, Nilgun11; Ilhan, Inci Ergurhan11; Sari, Neriman11; Serra, Massimo12; Hattinger, Claudia12; Picci, Piero12; Spector, Logan G.13; Barkauskas, Donald A.14; Marina, Neyssa15,16; Caminada de Toledo, Silvia Regina17; Petrilli, Antonio S.17; Amary, Maria Fernanda8; Halai, Dina8; Thomas, David M.18; Douglass, Chester19; Meltzer, Paul S.6; Jacobs, Kevin2; Chung, Charles C.2; Berndt, Sonja I.1; Purdue, Mark P.1; Caporaso, Neil E.1; Tucker, Margaret1; Rothman, Nathaniel1; Landi, Maria Teresa1; Silverman, Debra T.1; Kraft, Peter19; Hunter, David J.19; Malats, Nuria20; Kogevinas, Manolis21,22,23,24; Wacholder, Sholom1; Troisi, Rebecca1; Helman, Lee6; Fraumeni, Joseph F., Jr.1; Yeager, Meredith2; Hoover, Robert N.1; Chanock, Stephen J.1 | |
| 通讯作者 | Savage, Sharon A. |
| 来源期刊 | NATURE GENETICS
 |
| ISSN | 1061-4036 |
| EISSN | 1546-1718 |
| 出版年 | 2013 |
| 卷号 | 45期号:7页码:799-803 |
| 英文摘要 | Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. To better understand the genetic etiology of osteosarcoma, we performed a multistage genome-wide association study consisting of 941 individuals with osteosarcoma (cases) and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: a locus in the GRM4 gene at 6p21.3 (encoding glutamate receptor metabotropic 4; rs1906953; P = 8.1 x 10(-9)) and a locus in the gene desert at 2p25.2 (rs7591996 and rs10208273; P = 1.0 x 10(-8) and 2.9 x 10(-7), respectively). These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma. |
| 类型 | Article |
| 语种 | 英语 |
| 国家 | USA ; England ; Canada ; Spain ; Turkey ; Italy ; Brazil ; Australia ; Greece |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000321005200015 |
| WOS关键词 | GENETIC-VARIATION ; RECOMBINATION HOTSPOTS ; LINKAGE DISEQUILIBRIUM ; BONE CANCER ; POLYMORPHISMS ; CHILDREN ; RECEPTOR ; COMMON ; TUMOR ; RATES |
| WOS类目 | Genetics & Heredity |
| WOS研究方向 | Genetics & Heredity |
| 来源机构 | University of London |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/178996 |
| 作者单位 | 1.NCI, Div Canc Epidemiol & Genet, US NIH, Bethesda, MD 20892 USA; 2.NCI, Canc Genom Res Lab, Div Canc Epidemiol & Genet, SAIC Frederick Inc,NCI Frederick, Frederick, MD 21701 USA; 3.Nationwide Childrens Hosp, Columbus, OH USA; 4.Ohio State Univ, Dept Pathol & Pediat, Columbus, OH 43210 USA; 5.Childrens Hosp Montefiore, Albert Einstein Coll Med, Bronx, NY USA; 6.NCI, Ctr Canc Res, US NIH, Bethesda, MD 20892 USA; 7.UCL, Inst Canc, London, England; 8.Royal Natl Orthopaed Hosp NHS Trust, Stanmore, Middx, England; 9.Univ Toronto, Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Litwin Ctr Canc Genet, Toronto, ON M5G 1X5, Canada; 10.Univ Navarra, Univ Navarra Clin, Dept Pediat, E-31080 Pamplona, Spain; 11.AY Ankara Oncol Training & Res Hosp, Dept Pediat Oncol, Ankara, Turkey; 12.Orthopaed Rizzoli Inst, Expt Oncol Lab, Bologna, Italy; 13.Univ Minnesota, Dept Pediat, Div Epidemiol & Clin Res, Minneapolis, MN 55455 USA; 14.Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA; 15.Stanford Univ, Palo Alto, CA 94304 USA; 16.Lucile Packard Childrens Hosp, Dept Pediat Hematol Oncol, Palo Alto, CA USA; 17.Univ Fed Sao Paulo UNIFESP, Grp Apoio Adolescente & Crianca Com Canc GRAACC, Pediat Oncol Inst, Sao Paulo, Brazil; 18.Univ Melbourne, Sir Peter MacCallum Dept Oncol, East Melbourne, Vic, Australia; 19.Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA; 20.Ctr Nacl Invest Oncol, Madrid, Spain; 21.Ctr Res Environm Epidemiol CREAL, Barcelona, Spain; 22.IMIM Hosp Mar Med Res Inst, Barcelona, Spain; 23.Network Biomed Res Ctr Epidemiol & Publ Hlth CIBE, Barcelona, Spain; 24.Natl Sch Publ Hlth, Athens, Greece |
| 推荐引用方式 GB/T 7714 | Savage, Sharon A.,Mirabello, Lisa,Wang, Zhaoming,et al. Genome-wide association study identifies two susceptibility loci for osteosarcoma[J]. University of London,2013,45(7):799-803. |
| APA | Savage, Sharon A..,Mirabello, Lisa.,Wang, Zhaoming.,Gastier-Foster, Julie M..,Gorlick, Richard.,...&Chanock, Stephen J..(2013).Genome-wide association study identifies two susceptibility loci for osteosarcoma.NATURE GENETICS,45(7),799-803. |
| MLA | Savage, Sharon A.,et al."Genome-wide association study identifies two susceptibility loci for osteosarcoma".NATURE GENETICS 45.7(2013):799-803. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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