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This paper focuses on the determination of the most effective set of mitigation and adaptation strategies applied to combat land degradation and drought in a latitudinal gradient. This study was carried out in Chile, in a latitude gradient between 17A degrees 30’s and 36A degrees 33’s. The northern regions are mostly formed by desert and dry land, which can be considered as marginal areas for agriculture. On the other hand, the area formed by the southern regions has an industrialized agriculture where an increased use of technology takes place and where the climate and water availability are optimal for the development of agriculture. The period considered in this study was between 2000 and 2007. We calculated an Investment Effectiveness Index. Afterwards, and in order to assess the effectiveness of the financial support, we performed multiple regressions (P a parts per thousand currency signaEuro parts per thousand 0.05), where the Index was considered as the independent variable, and the annual difference of the area affected by a high risk of desertification was considered as the dependent variable. Our findings suggest that the effectiveness of the different set of the strategies applied to fight against desertification and drought varies in a latitudinal gradient. Thus, in arid and hyper arid areas the promotion of modern irrigation systems seems to be effective in combating desertification, while in Mediterranean climates the reforestation strategies seem to play an important role. Our results suggest that in areas heavily degraded by overgrazing, the most effective strategies are those oriented to obtain a permanent vegetation cover on degraded soils.