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Guided by radiative transfer modeling of the effects of dust (aerosol) on satellite thermal infrared radiance by many different imaging radiometers, in this article, we present the aerosol-effected satellite radiative signal changes in the top of atmosphere (TOA). The simulation of TOA radiance for Infrared Atmospheric Sounding Interferometer (IASI) is performed by using the RTTOV fast radiative transfer model. The model computation is carried out with setting representative geographical atmospheric models and typical default aerosol climatological models under clear sky condition. The radiative differences (in units of equivalent black body brightness temperature differences (BTDs)) between simulated radiances without consideration of the impact of aerosol (Aerosol-free) and with various aerosol models (Aerosol-modified) are calculated for the whole IASI spectrum between 3.62 and 15.5 mu m. The comparisons of BTDs are performed through 11 aerosol models in 5 classified atmospheric models. The results show that the Desert aerosol model has the most significant impact on IASI spectral simulated radiances than the other aerosol models (Continental, Urban, Maritime types and so on) in Mid-latitude Summer, contributing to the mineral aerosol components contained. The value of BTDs could reach up to 1 K at peak points. The atmospheric window spectral region between 900 and 1100 cm(-1) (9.09-11.11 mu m) is concentrated after the investigation for the largest values of aerosol-affected radiance differences. BTDs in IASI spectral region between 645 and 1200 cm(-1) occupies the largest oscillation and the major part of the whole spectrum. The IASI highest window peak-points channels (such as 9.4 and 10.2 mu m) are obtained finally, which are the most sensitive ones to the simulated IASI radiance. (C) 2013 Published by Elsevier Ltd.