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DOI10.1016/j.jpba.2013.05.029
Solid-phase extraction of galloyl- and caffeoylquinic acids from natural sources (Galphimia glauca and Arnicae flos) using pure zirconium silicate and bismuth citrate powders as sorbents inside micro spin columns
Hussain, Shah1; Schoenbichler, Stefan A.1; Guezel, Yueksel1; Sonderegger, Harald1; Abel, Gudrun2; Rainer, Matthias1; Huck, Christian W.1; Bonn, Guenther K.1
通讯作者Huck, Christian W.
来源期刊JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN0731-7085
出版年2013
卷号84页码:148-158
英文摘要

Galloyl- and caffeoylquinic acids are among the most important pharmacological active groups of natural compounds. This study describes a pre-step in isolation of some selected representatives of these groups from biological samples. A selective solid-phase extraction (SPE) method for these compounds may help assign classes and isomer designations within complex mixtures. Pure zirconium silicate and bismuth citrate powders (325 mesh) were employed as two new sorbents for optimized SPE of phenolic acids. These sorbents possess electrostatic interaction sites which accounts for additional interactions for carbon acid moieties as compared to hydrophilic and hydrophobic sorbents alone. Based on this principle, a selective SPE method for 1,3,4,5-tetragalloylquinic acid (an anti-HIV and anti-asthamatic agent) as a starting compound was developed and then deployed upon other phenolic acids with success. The recoveries and selectivities of both sorbents were compared to most commonly applied and commercially available sorbents by using high performance liquid chromatography. The nature of interaction between the carrier sorbent and the acidic target molecules was investigated by studying hydrophilic (silica), hydrophobic (C18), mixed-mode (ionic and hydrophobic: Oasis (R) MAX) and predominantly electrostatic (zirconium silicate) materials. The newly developed zirconium silicate and bismuth citrate stationary phases revealed promising results for the selective extraction of galloyl- and caffeoylquinic acids from natural sources. It was observed that zirconium silicate exhibited maximum recovery and selectivity for tetragalloylquinic acid (84%), chlorogenic acid (82%) and dicaffeoylquinic acid (94%) among all the tested sorbents. (C) 2013 Elsevier B.V. All rights reserved.


英文关键词Solid-phase extraction Zirconium silicate Bismuth citrate Phenolic acids Galphimia glauca Arnicae flos
类型Article
语种英语
国家Austria ; Germany
收录类别SCI-E
WOS记录号WOS:000322752800022
WOS关键词PERFORMANCE LIQUID-CHROMATOGRAPHY ; INDUCED CELL-DEATH ; CHLOROGENIC ACID ; CAFFEIC ACID ; QUINIC ACID ; MASS-SPECTROMETRY ; PHENOLIC-ACIDS ; TANNIC-ACID ; IN-VITRO ; DERIVATIVES
WOS类目Chemistry, Analytical ; Pharmacology & Pharmacy
WOS研究方向Chemistry ; Pharmacology & Pharmacy
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/178615
作者单位1.Leopold Franzens Univ, CCB Ctr Chem & Biomed, Inst Analyt Chem & Radiochem, A-6020 Innsbruck, Austria;
2.Bionorica SE, D-92318 Neumarkt, Germany
推荐引用方式
GB/T 7714
Hussain, Shah,Schoenbichler, Stefan A.,Guezel, Yueksel,et al. Solid-phase extraction of galloyl- and caffeoylquinic acids from natural sources (Galphimia glauca and Arnicae flos) using pure zirconium silicate and bismuth citrate powders as sorbents inside micro spin columns[J],2013,84:148-158.
APA Hussain, Shah.,Schoenbichler, Stefan A..,Guezel, Yueksel.,Sonderegger, Harald.,Abel, Gudrun.,...&Bonn, Guenther K..(2013).Solid-phase extraction of galloyl- and caffeoylquinic acids from natural sources (Galphimia glauca and Arnicae flos) using pure zirconium silicate and bismuth citrate powders as sorbents inside micro spin columns.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,84,148-158.
MLA Hussain, Shah,et al."Solid-phase extraction of galloyl- and caffeoylquinic acids from natural sources (Galphimia glauca and Arnicae flos) using pure zirconium silicate and bismuth citrate powders as sorbents inside micro spin columns".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 84(2013):148-158.
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