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DOI | 10.1016/j.jpba.2013.05.029 |
Solid-phase extraction of galloyl- and caffeoylquinic acids from natural sources (Galphimia glauca and Arnicae flos) using pure zirconium silicate and bismuth citrate powders as sorbents inside micro spin columns | |
Hussain, Shah1; Schoenbichler, Stefan A.1; Guezel, Yueksel1; Sonderegger, Harald1; Abel, Gudrun2; Rainer, Matthias1; Huck, Christian W.1; Bonn, Guenther K.1 | |
通讯作者 | Huck, Christian W. |
来源期刊 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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ISSN | 0731-7085 |
出版年 | 2013 |
卷号 | 84页码:148-158 |
英文摘要 | Galloyl- and caffeoylquinic acids are among the most important pharmacological active groups of natural compounds. This study describes a pre-step in isolation of some selected representatives of these groups from biological samples. A selective solid-phase extraction (SPE) method for these compounds may help assign classes and isomer designations within complex mixtures. Pure zirconium silicate and bismuth citrate powders (325 mesh) were employed as two new sorbents for optimized SPE of phenolic acids. These sorbents possess electrostatic interaction sites which accounts for additional interactions for carbon acid moieties as compared to hydrophilic and hydrophobic sorbents alone. Based on this principle, a selective SPE method for 1,3,4,5-tetragalloylquinic acid (an anti-HIV and anti-asthamatic agent) as a starting compound was developed and then deployed upon other phenolic acids with success. The recoveries and selectivities of both sorbents were compared to most commonly applied and commercially available sorbents by using high performance liquid chromatography. The nature of interaction between the carrier sorbent and the acidic target molecules was investigated by studying hydrophilic (silica), hydrophobic (C18), mixed-mode (ionic and hydrophobic: Oasis (R) MAX) and predominantly electrostatic (zirconium silicate) materials. The newly developed zirconium silicate and bismuth citrate stationary phases revealed promising results for the selective extraction of galloyl- and caffeoylquinic acids from natural sources. It was observed that zirconium silicate exhibited maximum recovery and selectivity for tetragalloylquinic acid (84%), chlorogenic acid (82%) and dicaffeoylquinic acid (94%) among all the tested sorbents. (C) 2013 Elsevier B.V. All rights reserved. |
英文关键词 | Solid-phase extraction Zirconium silicate Bismuth citrate Phenolic acids Galphimia glauca Arnicae flos |
类型 | Article |
语种 | 英语 |
国家 | Austria ; Germany |
收录类别 | SCI-E |
WOS记录号 | WOS:000322752800022 |
WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; INDUCED CELL-DEATH ; CHLOROGENIC ACID ; CAFFEIC ACID ; QUINIC ACID ; MASS-SPECTROMETRY ; PHENOLIC-ACIDS ; TANNIC-ACID ; IN-VITRO ; DERIVATIVES |
WOS类目 | Chemistry, Analytical ; Pharmacology & Pharmacy |
WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/178615 |
作者单位 | 1.Leopold Franzens Univ, CCB Ctr Chem & Biomed, Inst Analyt Chem & Radiochem, A-6020 Innsbruck, Austria; 2.Bionorica SE, D-92318 Neumarkt, Germany |
推荐引用方式 GB/T 7714 | Hussain, Shah,Schoenbichler, Stefan A.,Guezel, Yueksel,et al. Solid-phase extraction of galloyl- and caffeoylquinic acids from natural sources (Galphimia glauca and Arnicae flos) using pure zirconium silicate and bismuth citrate powders as sorbents inside micro spin columns[J],2013,84:148-158. |
APA | Hussain, Shah.,Schoenbichler, Stefan A..,Guezel, Yueksel.,Sonderegger, Harald.,Abel, Gudrun.,...&Bonn, Guenther K..(2013).Solid-phase extraction of galloyl- and caffeoylquinic acids from natural sources (Galphimia glauca and Arnicae flos) using pure zirconium silicate and bismuth citrate powders as sorbents inside micro spin columns.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,84,148-158. |
MLA | Hussain, Shah,et al."Solid-phase extraction of galloyl- and caffeoylquinic acids from natural sources (Galphimia glauca and Arnicae flos) using pure zirconium silicate and bismuth citrate powders as sorbents inside micro spin columns".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 84(2013):148-158. |
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