Arid
DOI10.1016/j.ibmb.2012.10.002
Regulation of feeding by Neuropeptide F in the desert locust, Schistocerca gregaria
Van Wielendaele, Pieter; Dillen, Senne; Zels, Sven; Badisco, Liesbeth; Vanden Broeck, Jozef
通讯作者Van Wielendaele, Pieter
来源期刊INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
ISSN0965-1748
EISSN1879-0240
出版年2013
卷号43期号:1页码:102-114
英文摘要

Our knowledge on the physiological function of the insect Neuropeptide F (NPF) mostly comes from studies in the fruit fly, Drosophila melanogaster, where NPF was shown to regulate diverse processes, such as feeding, learning and responding to stress. In the desert locust, Schistocerca gregaria, only a truncated form of the "full-length" NPF (the biologically active "trNPF’) has been isolated. In this study, we investigated whether this peptide is involved in the regulation of feeding in this orthopteran species. In the S. gregaria EST-database, an NPF-precursor encoding transcript was found. Alignment with other insect NPF-precursors showed relatively highest sequence conservation within the trNPF region (and the flanking dibasic cleavage site), as compared to other regions of the NPF-precursor. Quantitative real-time RT-PCR revealed that the Schgr-NPF-precursor encoding transcript occurs throughout the central nervous system with relatively high transcript levels in the brain, optic lobes and suboesophageal ganglion. It was also detected at relatively high levels in the midgut, which suggests that the encoded peptide also functions in the digestive system. Moreover, Schgr-NPF-transcript levels were notably higher in starved animals than in animals fed ad libitum, while transcript levels were also shown to be regulated after the consumption of a meal. Injection of locust trNPF in adults stimulated food intake, while RNAi knockdown reduced food intake. Furthermore, injection of trNPF in adults stimulated weight increase, while RNAi knockdown reduced weight gain. This effect of trNPF on body weight gain may result from its stimulatory effect on food intake. Taken together, we provide clear evidence for an important role of trNPF in the regulation of feeding in the desert locust, S. gregaria. (C) 2012 Elsevier Ltd. All rights reserved.


英文关键词Insect Hormone Regulatory peptide Food intake Weight gain
类型Article
语种英语
国家Belgium
收录类别SCI-E
WOS记录号WOS:000313934800011
WOS关键词Y-LIKE ; MIGRATORY LOCUST ; INSULIN-LIKE ; RHODNIUS-PROLIXUS ; ANOPHELES-GAMBIAE ; ADULT DEVELOPMENT ; NERVOUS-SYSTEM ; DROSOPHILA ; PEPTIDES ; IDENTIFICATION
WOS类目Biochemistry & Molecular Biology ; Entomology
WOS研究方向Biochemistry & Molecular Biology ; Entomology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/177649
作者单位Katholieke Univ Leuven, Inst Zool, Dept Anim Physiol & Neurobiol, Mol Dev Physiol & Signal Transduct, B-3000 Louvain, Belgium
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Van Wielendaele, Pieter,Dillen, Senne,Zels, Sven,et al. Regulation of feeding by Neuropeptide F in the desert locust, Schistocerca gregaria[J],2013,43(1):102-114.
APA Van Wielendaele, Pieter,Dillen, Senne,Zels, Sven,Badisco, Liesbeth,&Vanden Broeck, Jozef.(2013).Regulation of feeding by Neuropeptide F in the desert locust, Schistocerca gregaria.INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY,43(1),102-114.
MLA Van Wielendaele, Pieter,et al."Regulation of feeding by Neuropeptide F in the desert locust, Schistocerca gregaria".INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 43.1(2013):102-114.
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