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Controlling the confounding factors on respiratory hospitalizations such as long-term trend, meteorological factor, atmospheric pollution, and calendar effect, the research is designed to study the effect of sand-dust weather on respiratory diseases from 2001 to 2005 in Lanzhou City on the basis of the semi-parametric generalized additive model (GAM). The results indicate that there is an association between sand-dust weather and the increase in respiratory hospitalizations, and with lagging effect. There are gender and age differences in the effect of sand-dust weather on health, on male severer than on female (RR value being 1.148 for male, while 1.144 for female without statistical significance), and much greater on the aged >= 65 years than on <65 years (RR value being 1.266 for >= 65 yr. and 1.119 for <65 yr). (C) 2012 Elsevier B.V. All rights reserved.