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Sweet sorghum (Sorghum bicolor L.) is an important crop in Iran. Different concentrations of sodium in saline water were compared for potential of forage yield in two cultivars of sweet sorghum in 2011. Crop was irrigated by saline water with different electrical conductivity such as EC=1.75 milimohs/cm (T-1), -EC=2.75 milimohs/cm (T-2), 50% saline water with EC=3.75 milimohs/cm and 50% sweet water (T-3) and control, irrigated by sweet water (T-4). IR 2240 and 6826 had less forage yield in T-2 and T-3 treatments in response to salt stress than T-1 and T-4 treatments (21.3 to 43.2% and 25.8 to 47.2%, respectively). A difference in total sugar concentration was found at harvest time and indicated that saline water could decrease the yield of sugar in sweet sorghum or salt stress had direct effect in our study (reduction of sugar in T-2 and T-3 about 20.8 to 27% in 6826 and 15.7 to 23.4% in IR 2240 as compared with T-1 and control). At least saline water is harmful for crops, and this is the main factor for reduction of yield in semi-arid regions in Iran.