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DOI | 10.1371/journal.pone.0047984 |
Changes in the Diurnal Rhythms during a 45-Day Head-Down Bed Rest | |
Liang, Xiaodi1; Zhang, Lin1; Wan, Yufeng1; Yu, Xinyang1; Guo, Yiming1; Chen, Xiaoping2; Tan, Cheng2; Huang, Tianle1; Shen, Hanjie1; Chen, Xianyun1; Li, Hongying1; Lv, Ke2; Sun, Fei3,4; Chen, Shanguang2; Guo, Jinhu1 | |
通讯作者 | Guo, Jinhu |
来源期刊 | PLOS ONE |
ISSN | 1932-6203 |
出版年 | 2012 |
卷号 | 7期号:10 |
英文摘要 | In spaceflight human circadian rhythms and sleep patterns are likely subject to change, which consequently disturbs human physiology, cognitive abilities and performance efficiency. However, the influence of microgravity on sleep and circadian clock as well as the underlying mechanisms remain largely unknown. Placing volunteers in a prone position, whereby their heads rest at an angle of -6 degrees below horizontal, mimics the microgravity environment in orbital flight. Such positioning is termed head-down bed rest (HDBR). In this work, we analysed the influence of a 45-day HDBR on physiological diurnal rhythms. We examined urinary electrolyte and hormone excretion, and the results show a dramatic elevation of cortisol levels during HDBR and recovery. Increased diuresis, melatonin and testosterone were observed at certain periods during HDBR. In addition, we investigated the changes in urination and defecation frequencies and found that the rhythmicity of urinary frequency during lights-off during and after HDBR was higher than control. The grouped defecation frequency data exhibits rhythmicity before and during HDBR but not after HDBR. Together, these data demonstrate that HDBR can alter a number of physiological processes associated with diurnal rhythms. |
类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
收录类别 | SCI-E |
WOS记录号 | WOS:000310310200127 |
WOS关键词 | CIRCADIAN-RHYTHMS ; TRIGONOSCELIS-GIGAS ; DESERT BEETLE ; SPACE ; HUMANS ; CLOCK ; SLEEP ; SPACEFLIGHT ; CORTISOL ; COUNTERMEASURE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/174570 |
作者单位 | 1.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Minist Educ,Key Lab Gene Engn, Guangzhou 510275, Guangdong, Peoples R China; 2.China Astronaut Res & Training Ctr, State Key Lab Space Med Fundamentals & Applicat, Beijing, Peoples R China; 3.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China; 4.Hefei Natl Lab Phys Sci Microscale, Hefei, Peoples R China |
推荐引用方式 GB/T 7714 | Liang, Xiaodi,Zhang, Lin,Wan, Yufeng,et al. Changes in the Diurnal Rhythms during a 45-Day Head-Down Bed Rest[J],2012,7(10). |
APA | Liang, Xiaodi.,Zhang, Lin.,Wan, Yufeng.,Yu, Xinyang.,Guo, Yiming.,...&Guo, Jinhu.(2012).Changes in the Diurnal Rhythms during a 45-Day Head-Down Bed Rest.PLOS ONE,7(10). |
MLA | Liang, Xiaodi,et al."Changes in the Diurnal Rhythms during a 45-Day Head-Down Bed Rest".PLOS ONE 7.10(2012). |
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