Arid
DOI10.1038/ncomms1971
Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation
Saito, Atsushi1; Kanemoto, Soshi1; Kawasaki, Noritaka1; Asada, Rie1; Iwamoto, Hideo1; Oki, Mami1; Miyagi, Hidetaka1; Izumi, Soutarou1; Sanosaka, Tsukasa2; Nakashima, Kinichi2; Imaizumi, Kazunori1
通讯作者Imaizumi, Kazunori
来源期刊NATURE COMMUNICATIONS
ISSN2041-1723
出版年2012
卷号3
英文摘要

ASIS is a member of the CREB/ATF family of transcription factors and modulates cell-or tissue-specific unfolded protein response signalling. Here we show that this modulation has a critical role in the differentiation of neural precursor cells into astrocytes. Cerebral cortices of mice specifically deficient in OASIS (Oasis(-/-)) contain fewer astrocytes and more neural precursor cells than those of wild-type mice during embryonic development. Furthermore, astrocyte differentiation is delayed in primary cultured Oasis(-/-) neural precursor cells. The transcription factor Gcm1, which is necessary for astrocyte differentiation in Drosophila, is revealed to be a target of OASIS. Introduction of Gcm1 into Oasis(-/-) neural precursor cells improves the delayed differentiation of neural precursor cells into astrocytes by accelerating demethylation of the Gfap promoter. Gcm1 expression is temporally controlled by the unfolded protein response through interactions between OASIS family members during astrocyte differentiation. Taken together, our findings demonstrate a novel mechanism by which OASIS and its associated family members are modulated by the unfolded protein response to finely control astrocyte differentiation.


类型Article
语种英语
国家Japan
收录类别SCI-E
WOS记录号WOS:000306995000039
WOS关键词ENDOPLASMIC-RETICULUM STRESS ; CREB/ATF-FAMILY ; NERVOUS-SYSTEM ; FETAL-BRAIN ; CELLS ; DROSOPHILA ; ELEMENT ; PATHWAY ; BINDING ; GENES
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/174157
作者单位1.Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Biochem, Minami Ku, Hiroshima 7348553, Japan;
2.Nara Inst Sci & Technol, Grad Sch Biol Sci, Lab Mol Neurosci, Nara 6300101, Japan
推荐引用方式
GB/T 7714
Saito, Atsushi,Kanemoto, Soshi,Kawasaki, Noritaka,et al. Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation[J],2012,3.
APA Saito, Atsushi.,Kanemoto, Soshi.,Kawasaki, Noritaka.,Asada, Rie.,Iwamoto, Hideo.,...&Imaizumi, Kazunori.(2012).Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation.NATURE COMMUNICATIONS,3.
MLA Saito, Atsushi,et al."Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation".NATURE COMMUNICATIONS 3(2012).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Saito, Atsushi]的文章
[Kanemoto, Soshi]的文章
[Kawasaki, Noritaka]的文章
百度学术
百度学术中相似的文章
[Saito, Atsushi]的文章
[Kanemoto, Soshi]的文章
[Kawasaki, Noritaka]的文章
必应学术
必应学术中相似的文章
[Saito, Atsushi]的文章
[Kanemoto, Soshi]的文章
[Kawasaki, Noritaka]的文章
相关权益政策
暂无数据
收藏/分享

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。