Arid
DOI10.1242/jeb.054403
Aestivation: signaling and hypometabolism
Storey, Kenneth B.; Storey, Janet M.
通讯作者Storey, Kenneth B.
来源期刊JOURNAL OF EXPERIMENTAL BIOLOGY
ISSN0022-0949
出版年2012
卷号215期号:9页码:1425-1433
英文摘要

Aestivation is a survival strategy used by many vertebrates and invertebrates to endure arid environmental conditions. Key features of aestivation include strong metabolic rate suppression, strategies to retain body water, conservation of energy and body fuel reserves, altered nitrogen metabolism, and mechanisms to preserve and stabilize organs, cells and macromolecules over many weeks or months of dormancy. Cell signaling is crucial to achieving both a hypometabolic state and reorganizing multiple metabolic pathways to optimize long-term viability during aestivation. This commentary examines the current knowledge about cell signaling pathways that participate in regulating aestivation, including signaling cascades mediated by the AMP-activated kinase, Akt, ERK, and FoxO1.


英文关键词antioxidant defense metabolic rate depression regulation of gene expression reversible protein phosphorylation signal transduction pathway signaling cascade
类型Article
语种英语
国家Canada
收录类别SCI-E
WOS记录号WOS:000302786300009
WOS关键词METABOLIC-RATE DEPRESSION ; ACTIVATED PROTEIN-KINASE ; AFRICAN CLAWED FROG ; SNAIL OTALA-LACTEA ; ALBOGUTTATA GUNTHER 1867 ; LAND SNAIL ; XENOPUS-LAEVIS ; CYCLORANA-ALBOGUTTATA ; ANTIOXIDANT DEFENSES ; DEHYDRATION STRESS
WOS类目Biology
WOS研究方向Life Sciences & Biomedicine - Other Topics
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/173503
作者单位Carleton Univ, Inst Biochem, Ottawa, ON K1S 5B6, Canada
推荐引用方式
GB/T 7714
Storey, Kenneth B.,Storey, Janet M.. Aestivation: signaling and hypometabolism[J],2012,215(9):1425-1433.
APA Storey, Kenneth B.,&Storey, Janet M..(2012).Aestivation: signaling and hypometabolism.JOURNAL OF EXPERIMENTAL BIOLOGY,215(9),1425-1433.
MLA Storey, Kenneth B.,et al."Aestivation: signaling and hypometabolism".JOURNAL OF EXPERIMENTAL BIOLOGY 215.9(2012):1425-1433.
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