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Intercropping is a common practice in Africa, but the advantage compared to sole cropping depends on the crop plants and local agro-ecological conditions. The potential of intercroppingmaize (Zea mays) or sorghum (Sorghum bicolor) with watermelon (Citrullus lanatus) was tested in two on-farm trials in southern Mozambique under semi-arid conditions in an area with low and unpredictable rainfall. In the first experiment, plant density, yield and monetary value of sole and intercropping plots of maize with watermelon were determined in 17 farmers’ fields in an area where all crops developed to maturity and harvest. There was a significant reduction in yield of both maize (28.8%) and watermelon (57.8%) in the intercrop compared with the sole crop yields. However, the mean land equivalent ratio of 1.13 for yield showed that intercropping had advantages as, on average, an area planted with sole crops would require 13% more land than an intercrop production to generate the same outcome. In the second experiment, carried out in another area with 16 farmers’ fields, drought was more pronounced and only watermelon developed to maturity. Intercroppings with maize and sorghum resulted in 70% and 69% yield reduction, respectively. In conclusion, watermelon is a good companion crop for intercropping with cereals to mitigate the risk of total crop failure due to drought.