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DOI | 10.1016/j.diff.2011.10.006 |
Hedgehog signaling regulates myelination in the peripheral nervous system through primary cilia | |
Yoshimura, Kentaro; Takeda, Sen | |
通讯作者 | Takeda, Sen |
来源期刊 | DIFFERENTIATION |
ISSN | 0301-4681 |
EISSN | 1432-0436 |
出版年 | 2012 |
卷号 | 83期号:2页码:S78-S85 |
英文摘要 | Myelination is an essential prerequisite for the nervous system to transmit an impulse efficiently by a saltatory conduction. In the peripheral nervous system (MIS), Schwann cells (SCs) engage in myelination. However, a detailed molecular mechanism underlying myelination still remains unclear. In this study, we hypothesized that the primary cilia of SCs are the regulators of Hedgehog (Hh) signaling-mediated myelination. To confirm our hypothesis, we used mouse dorsal root ganglion (DRG)/SC co-cultures, wherein the behavior of SCs could be analyzed by maintaining the interaction of SCs with DRG neurons. Under these conditions, SCs had primary cilia, and Hh signaling molecules accumulated on the primary cilia. When the SCs were stimulated by the addition of desert hedgehog or smoothened agonist, formation of myelin segments on the DRG axons was facilitated. On the contrary, upon administration of cyclopamine, an inhibitor of Hh signaling, myelin segments became comparable to those of controls. Of note, the ratio of SCs harboring primary cilium reached the highest point during the early phase of myelination. Furthermore, the strongest effects of Hh on myelination were encountered during the same stage. These results collectively indicate that Hh signaling regulates myelin formation through primary cilia in the MIS. (C) 2011 International Society of Differentiation. Published by Elsevier B.V. All rights reserved. |
英文关键词 | Myelination Primary cilia Hedgehog signaling Schwann cell |
类型 | Article |
语种 | 英语 |
国家 | Japan |
收录类别 | SCI-E |
WOS记录号 | WOS:000300191200011 |
WOS关键词 | SCHWANN-CELL ; DESERT-HEDGEHOG ; NERVES ; MICE ; RAT ; DIFFERENTIATION ; EXPRESSION ; GROWTH ; AXON ; ADENOHYPOPHYSIS |
WOS类目 | Cell Biology ; Developmental Biology |
WOS研究方向 | Cell Biology ; Developmental Biology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/171947 |
作者单位 | Univ Yamanashi, Dept Anat & Cell Biol, Interdisciplinary Grad Sch Med & Engn, Chuo Ku, Yamanashi 4093898, Japan |
推荐引用方式 GB/T 7714 | Yoshimura, Kentaro,Takeda, Sen. Hedgehog signaling regulates myelination in the peripheral nervous system through primary cilia[J],2012,83(2):S78-S85. |
APA | Yoshimura, Kentaro,&Takeda, Sen.(2012).Hedgehog signaling regulates myelination in the peripheral nervous system through primary cilia.DIFFERENTIATION,83(2),S78-S85. |
MLA | Yoshimura, Kentaro,et al."Hedgehog signaling regulates myelination in the peripheral nervous system through primary cilia".DIFFERENTIATION 83.2(2012):S78-S85. |
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