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The experiment evaluated the apparent digestibility coefficient (CDA) of dry matter (DM), gross energy (GE), ether extract (EE) and crude protein (CP) of regional alternative ingredients of Semi-arid Northeast as flour of manicoba hay (FM), of Leucaena hay (FL) and of cassava leaves (FFM), as well as cassava scrapings (RM) and residues of wine (RV) for Nile tilapia (Oreochromis niloticus). CDA for DM, GE, EE and CP were 20.74%, 30.30%, 48.36% and 71.72% for FL, 19.34%, 17.08%, 30.03% and 44.88% for FM, 30.32%, 23.04%, 4.43% and 21.07% for FFM, 72.85%, 70.62%, 81.78% and 84.51% for RM and 33.38%, 50.80%, 79.39% and 67.25% for RV. The leucaena hay, the cassava scrapings and residues of wine are promising for the formulation of diets for Nile tilapia. However, the use of tested ingredients in commercial and homemade diets to Nile tilapia, as well as the safe inclusion levels of these should be tested.