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The TMS5e sequence from the Tumen section, at the southern edge of Tengger Desert in the northwestern China, is synchronous with Marine Isotope Stage 5e (MIS5e). It consists of 16 layers of aeolian dune sands, 11 layers of lacustrine loess-like facies, and 5 layers of lacustrine facies. The results of grain-size analysis shows that the palaeo-mobile dune sands, palaeo-fixed to semi-fixed dune sands and loess-like sandy loams are mainly composed of sands, ranging from 70% to 96%; their silt contents ranged from 4% to 20%, and their clay contents ranged from 1% to 5%; the climate under which the aeolian dune sands were deposited is similar to that under which modern mobile dune sands form, which is caused by the dominance of the cold, dry East Asian winter monsoon. In contrast, the lacustrine loess-like facies and lacustrine facies had a lower sand contents than those of the three aeolian dune sands, but have higher silt and clay contents, most of their sand content ranged from 30% to 60%, their silt contents ranged from 35% to 55%, and their clay contents ranged from 6% to 20%. The lacustrine loess-like facies and lacustrine facies formed under the influence of the warm, humid East Asian summer monsoon based on their similarity with modern sediments. The grain-size indicator Mz (mean grain diameter) and the SC/D value in the TMS5e sequence indicate climatic instability at the southern edge of the Tengger Desert during MIS5e, with at least 14 fluctuations between a warm, humid climate and a cold, dry climate, divided into five stages: TMS5e5 (139 kyr to 129.3 kyr B.P.), TMS5e4 (129.3 kyr to 124 kyr B.P.), TMS5e3 (124 kyr to 119.5 kyr B.P.), TMS5e2 (119.5 kyr to 116.5 kyr B.P.), and TMS5e1 (116.5 kyr to 113.7 kyr B.P.). These correspond roughly to MIS5e5, MIS5e4, MIS5e3, MIS5e2, and MIS5e1, respectively, in the GRIP ice core data.