Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1186/1471-2164-13-53 |
Gene alterations at Drosophila inversion breakpoints provide prima facie evidence for natural selection as an explanation for rapid chromosomal evolution | |
Guillen, Yolanda; Ruiz, Alfredo | |
通讯作者 | Ruiz, Alfredo |
来源期刊 | BMC GENOMICS
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ISSN | 1471-2164 |
出版年 | 2012 |
卷号 | 13 |
英文摘要 | Background: Chromosomal inversions have been pervasive during the evolution of the genus Drosophila, but there is significant variation between lineages in the rate of rearrangement fixation. D. mojavensis, an ecological specialist adapted to a cactophilic niche under extreme desert conditions, is a chromosomally derived species with ten fixed inversions, five of them not present in any other species. Results: In order to explore the causes of the rapid chromosomal evolution in D. mojavensis, we identified and characterized all breakpoints of seven inversions fixed in chromosome 2, the most dynamic one. One of the inversions presents unequivocal evidence for its generation by ectopic recombination between transposon copies and another two harbor inverted duplications of non-repetitive DNA at the two breakpoints and were likely generated by staggered single-strand breaks and repair by non-homologous end joining. Four out of 14 breakpoints lay in the intergenic region between preexisting duplicated genes, suggesting an adaptive advantage of separating previously tightly linked duplicates. Four out of 14 breakpoints are associated with transposed genes, suggesting these breakpoints are fragile regions. Finally two inversions contain novel genes at their breakpoints and another three show alterations of genes at breakpoints with potential adaptive significance. Conclusions: D. mojavensis chromosomal inversions were generated by multiple mechanisms, an observation that does not provide support for increased mutation rate as explanation for rapid chromosomal evolution. On the other hand, we have found a number of gene alterations at the breakpoints with putative adaptive consequences that directly point to natural selection as the cause of D. mojavensis rapid chromosomal evolution. |
英文关键词 | Inversion breakpoints mutation rate chromosomal evolution transposable elements gene duplication gene transposition position effects |
类型 | Article |
语种 | 英语 |
国家 | Spain |
收录类别 | SCI-E |
WOS记录号 | WOS:000304154700001 |
WOS关键词 | DEHYDROGENASE ADH PARALOGS ; GLUTATHIONE S-TRANSFERASES ; CACTOPHILIC DROSOPHILA ; TRANSPOSABLE ELEMENTS ; MOLECULAR EVOLUTION ; X-CHROMOSOME ; ECTOPIC RECOMBINATION ; GENOME REARRANGEMENTS ; SPECIES COMPLEX ; BUZZATII GENOME |
WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/171625 |
作者单位 | Univ Autonoma Barcelona, Dept Genet & Microbiol, Bellaterra 08193, Barcelona, Spain |
推荐引用方式 GB/T 7714 | Guillen, Yolanda,Ruiz, Alfredo. Gene alterations at Drosophila inversion breakpoints provide prima facie evidence for natural selection as an explanation for rapid chromosomal evolution[J],2012,13. |
APA | Guillen, Yolanda,&Ruiz, Alfredo.(2012).Gene alterations at Drosophila inversion breakpoints provide prima facie evidence for natural selection as an explanation for rapid chromosomal evolution.BMC GENOMICS,13. |
MLA | Guillen, Yolanda,et al."Gene alterations at Drosophila inversion breakpoints provide prima facie evidence for natural selection as an explanation for rapid chromosomal evolution".BMC GENOMICS 13(2012). |
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