Arid
DOI10.1186/1471-2164-13-53
Gene alterations at Drosophila inversion breakpoints provide prima facie evidence for natural selection as an explanation for rapid chromosomal evolution
Guillen, Yolanda; Ruiz, Alfredo
通讯作者Ruiz, Alfredo
来源期刊BMC GENOMICS
ISSN1471-2164
出版年2012
卷号13
英文摘要

Background: Chromosomal inversions have been pervasive during the evolution of the genus Drosophila, but there is significant variation between lineages in the rate of rearrangement fixation. D. mojavensis, an ecological specialist adapted to a cactophilic niche under extreme desert conditions, is a chromosomally derived species with ten fixed inversions, five of them not present in any other species.


Results: In order to explore the causes of the rapid chromosomal evolution in D. mojavensis, we identified and characterized all breakpoints of seven inversions fixed in chromosome 2, the most dynamic one. One of the inversions presents unequivocal evidence for its generation by ectopic recombination between transposon copies and another two harbor inverted duplications of non-repetitive DNA at the two breakpoints and were likely generated by staggered single-strand breaks and repair by non-homologous end joining. Four out of 14 breakpoints lay in the intergenic region between preexisting duplicated genes, suggesting an adaptive advantage of separating previously tightly linked duplicates. Four out of 14 breakpoints are associated with transposed genes, suggesting these breakpoints are fragile regions. Finally two inversions contain novel genes at their breakpoints and another three show alterations of genes at breakpoints with potential adaptive significance.


Conclusions: D. mojavensis chromosomal inversions were generated by multiple mechanisms, an observation that does not provide support for increased mutation rate as explanation for rapid chromosomal evolution. On the other hand, we have found a number of gene alterations at the breakpoints with putative adaptive consequences that directly point to natural selection as the cause of D. mojavensis rapid chromosomal evolution.


英文关键词Inversion breakpoints mutation rate chromosomal evolution transposable elements gene duplication gene transposition position effects
类型Article
语种英语
国家Spain
收录类别SCI-E
WOS记录号WOS:000304154700001
WOS关键词DEHYDROGENASE ADH PARALOGS ; GLUTATHIONE S-TRANSFERASES ; CACTOPHILIC DROSOPHILA ; TRANSPOSABLE ELEMENTS ; MOLECULAR EVOLUTION ; X-CHROMOSOME ; ECTOPIC RECOMBINATION ; GENOME REARRANGEMENTS ; SPECIES COMPLEX ; BUZZATII GENOME
WOS类目Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS研究方向Biotechnology & Applied Microbiology ; Genetics & Heredity
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/171625
作者单位Univ Autonoma Barcelona, Dept Genet & Microbiol, Bellaterra 08193, Barcelona, Spain
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GB/T 7714
Guillen, Yolanda,Ruiz, Alfredo. Gene alterations at Drosophila inversion breakpoints provide prima facie evidence for natural selection as an explanation for rapid chromosomal evolution[J],2012,13.
APA Guillen, Yolanda,&Ruiz, Alfredo.(2012).Gene alterations at Drosophila inversion breakpoints provide prima facie evidence for natural selection as an explanation for rapid chromosomal evolution.BMC GENOMICS,13.
MLA Guillen, Yolanda,et al."Gene alterations at Drosophila inversion breakpoints provide prima facie evidence for natural selection as an explanation for rapid chromosomal evolution".BMC GENOMICS 13(2012).
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