Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1242/bio.20122527 |
A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease | |
Sandmeier, Franziska C.1; Tracy, C. Richard1; Dupre, Sally2; Hunter, Kenneth2 | |
通讯作者 | Sandmeier, Franziska C. |
来源期刊 | BIOLOGY OPEN
![]() |
ISSN | 2046-6390 |
出版年 | 2012 |
卷号 | 1期号:11页码:1078-1082 |
英文摘要 | Vertebrate immune systems are understood to be complex and dynamic, with trade-offs among different physiological components (e.g., innate and adaptive immunity) within individuals and among taxonomic lineages. Desert tortoises (Gopherus agassizii) immunised with ovalbumin (OVA) showed a clear trade-off between levels of natural antibodies (NAbs; innate immune function) and the production of acquired antibodies (adaptive immune function). Once initiated, acquired antibody responses included a long-term elevation in antibodies persisting for more than one year. The occurrence of either (a) high levels of NAbs or (b) long-term elevations of acquired antibodies in individual tortoises suggests that long-term humoral resistance to pathogens may be especially important in this species, as well as in other vertebrates with slow metabolic rates, concomitantly slow primary adaptive immune responses, and long life-spans. (C) 2012. Published by The Company of Biologists Ltd. |
英文关键词 | Tortoise Ectothermic Innate immunity Adaptive immunity Natural antibodies Epitope masking |
类型 | Article |
语种 | 英语 |
国家 | USA |
收录类别 | SCI-E |
WOS记录号 | WOS:000209205600004 |
WOS类目 | Biology |
WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/171590 |
作者单位 | 1.Univ Nevada, Dept Biol, Ecol Evolut & Conservat Biol Program, Reno, NV 89557 USA; 2.Univ Nevada, Dept Microbiol & Immunol, Reno, NV 89557 USA |
推荐引用方式 GB/T 7714 | Sandmeier, Franziska C.,Tracy, C. Richard,Dupre, Sally,et al. A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease[J],2012,1(11):1078-1082. |
APA | Sandmeier, Franziska C.,Tracy, C. Richard,Dupre, Sally,&Hunter, Kenneth.(2012).A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease.BIOLOGY OPEN,1(11),1078-1082. |
MLA | Sandmeier, Franziska C.,et al."A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease".BIOLOGY OPEN 1.11(2012):1078-1082. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。