Arid
DOI10.1242/bio.20122527
A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease
Sandmeier, Franziska C.1; Tracy, C. Richard1; Dupre, Sally2; Hunter, Kenneth2
通讯作者Sandmeier, Franziska C.
来源期刊BIOLOGY OPEN
ISSN2046-6390
出版年2012
卷号1期号:11页码:1078-1082
英文摘要

Vertebrate immune systems are understood to be complex and dynamic, with trade-offs among different physiological components (e.g., innate and adaptive immunity) within individuals and among taxonomic lineages. Desert tortoises (Gopherus agassizii) immunised with ovalbumin (OVA) showed a clear trade-off between levels of natural antibodies (NAbs; innate immune function) and the production of acquired antibodies (adaptive immune function). Once initiated, acquired antibody responses included a long-term elevation in antibodies persisting for more than one year. The occurrence of either (a) high levels of NAbs or (b) long-term elevations of acquired antibodies in individual tortoises suggests that long-term humoral resistance to pathogens may be especially important in this species, as well as in other vertebrates with slow metabolic rates, concomitantly slow primary adaptive immune responses, and long life-spans. (C) 2012. Published by The Company of Biologists Ltd.


英文关键词Tortoise Ectothermic Innate immunity Adaptive immunity Natural antibodies Epitope masking
类型Article
语种英语
国家USA
收录类别SCI-E
WOS记录号WOS:000209205600004
WOS类目Biology
WOS研究方向Life Sciences & Biomedicine - Other Topics
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/171590
作者单位1.Univ Nevada, Dept Biol, Ecol Evolut & Conservat Biol Program, Reno, NV 89557 USA;
2.Univ Nevada, Dept Microbiol & Immunol, Reno, NV 89557 USA
推荐引用方式
GB/T 7714
Sandmeier, Franziska C.,Tracy, C. Richard,Dupre, Sally,et al. A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease[J],2012,1(11):1078-1082.
APA Sandmeier, Franziska C.,Tracy, C. Richard,Dupre, Sally,&Hunter, Kenneth.(2012).A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease.BIOLOGY OPEN,1(11),1078-1082.
MLA Sandmeier, Franziska C.,et al."A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease".BIOLOGY OPEN 1.11(2012):1078-1082.
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