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Major, trace, and REE data for three localities of calc-alkaline older granitoid rocks exposed in the north Eastern Desert of Egypt are presented. These rocks were selected to cover wide compositional spectrum of the Egyptian older granitoid varieties. They are petrographically represented by granodiorite, tonalite, quartz-diorite, and quartz-monzodiorite. The rocks are comparable with the peraluminous, unfractionated calc-alkaline suites and fall within the volcanic arc and I-type granite fields. So, they can be regarded as belonging to the volcanic arc collision stage (665-614 Ma). The granitoids are geochemically similar to other rocks recorded from continental margin arc-systems being exhibit light-REE enriched patterns with variable but chiefly positive Eu anomaly. The latter has reverse relationship with the I REE pound, which was attributed to the fractionation of hornblende during partial melting. These patterns are comparable with models involving partial melting of amphibolitic source. This source must represent basalts, gabbros, or volcanics of an island arc system that were transformed to the level of the island arc crust during continental growth where the P-T conditions are suitable for partial melting. Thus, it is plausible that the studied rocks were derived by partial melting of LREE-enriched, garnet-free, and amphibole-bearing (i.e., hydrated) mafic source. Wadi Milaha granitoids are consistent with the derivation by a high degree of partial melting (30-40%) of amphibolite protolith in the deep crust. However, the two other localities (Wadi Umm Anab and West Gharib) are matching with 20-30% partial melting. Within each locality, variation in rock types from granodiorite to tonalite is said to be dominated by variable degree of restite separation during magma ascent. The high water and volatile contents in Wadi Milaha granitoids allowed higher degree of partial melting (30-40%). Moreover, the lower volatile contents in the other two localities (Wadi Umm Anab and West Gharib) gave lower degrees of partial melting (20-30%). These processes may resemble important geodynamic features of the Arabo-Nubian Shield evolution in the north Eastern Desert of Egypt.