Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1007/s00216-012-6139-8 |
Analysis of selected pharmaceuticals in fish and the fresh water bodies directly affected by reclaimed water using liquid chromatography-tandem mass spectrometry | |
Wang, Jian1,2; Gardinali, Piero R.1,2 | |
通讯作者 | Gardinali, Piero R. |
来源期刊 | ANALYTICAL AND BIOANALYTICAL CHEMISTRY
![]() |
ISSN | 1618-2642 |
出版年 | 2012 |
卷号 | 404期号:9页码:2711-2720 |
英文摘要 | A comprehensive method for the analysis of 11 target pharmaceuticals representing multiple commonly used therapeutic classes was developed for biological tissues (fish), reclaimed water, and the surface water directly affected by irrigation with reclaimed water. One gram of fish tissue homogenate was extracted by accelerated solvent extraction with methylene chloride followed by mixed-mode cation exchange solid phase extraction (SPE) cleanup and analyzed by liquid chromatography-tandem mass spectrometry. Compared to previously reported methods, the protocol produces cleaner extracts resulting in lower method detection limits. Similarly, an SPE method based on Oasis HLB cartridges was used to concentrate and cleanup reclaimed and surface water samples. Among the 11 target compounds analyzed, trimethoprim, caffeine, sulfamethoxazole, diphenhydramine, diltiazem, carbamazepine, erythromycin, and fluoxetine were consistently detected in reclaimed water. Caffeine, diphenhydramine, and carbamazepine were consistently detected in fish and surface water samples. Bioaccumulation factors for caffeine, diphenhydramine, and carbamazepine in mosquito fish (Gambusia holbrooki) were calculated at 29 +/- 26, 821 +/- 422, and 108 +/- 144, respectively. This is the first report of potential accumulation of caffeine in fish from a water body directly influenced by reclaimed water. |
英文关键词 | Pharmaceuticals Fish LC-MS/MS |
类型 | Article |
语种 | 英语 |
国家 | USA |
收录类别 | SCI-E |
WOS记录号 | WOS:000310339400014 |
WOS关键词 | SOLID-PHASE EXTRACTION ; PERSONAL CARE PRODUCTS ; ACCELERATED SOLVENT-EXTRACTION ; AQUATIC ENVIRONMENT ; GAS-CHROMATOGRAPHY ; UV FILTERS ; ANTIBIOTICS ; BIOACCUMULATION ; FLUOXETINE ; ANTIDEPRESSANTS |
WOS类目 | Biochemical Research Methods ; Chemistry, Analytical |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/171175 |
作者单位 | 1.Florida Int Univ, Dept Chem & Biochem, N Miami, FL 33181 USA; 2.Florida Int Univ, SE Environm Res Ctr, N Miami, FL 33181 USA |
推荐引用方式 GB/T 7714 | Wang, Jian,Gardinali, Piero R.. Analysis of selected pharmaceuticals in fish and the fresh water bodies directly affected by reclaimed water using liquid chromatography-tandem mass spectrometry[J],2012,404(9):2711-2720. |
APA | Wang, Jian,&Gardinali, Piero R..(2012).Analysis of selected pharmaceuticals in fish and the fresh water bodies directly affected by reclaimed water using liquid chromatography-tandem mass spectrometry.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,404(9),2711-2720. |
MLA | Wang, Jian,et al."Analysis of selected pharmaceuticals in fish and the fresh water bodies directly affected by reclaimed water using liquid chromatography-tandem mass spectrometry".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 404.9(2012):2711-2720. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。