Arid
DOI10.1016/j.apsb.2012.07.003
Simultaneous quantitation of lamivudine, zidovudine and nevirapine in human plasma by liquid chromatography-tandem mass spectrometry and application to a pharmacokinetic study
Matta, Murali Krishna1; Pilli, Nageswara Rao1; Inamadugu, Jaswanth Kumar2; Burugula, Laxminarayana1; Rao, Seshagiri J. V. L. N.3
通讯作者Rao, Seshagiri J. V. L. N.
来源期刊ACTA PHARMACEUTICA SINICA B
ISSN2211-3835
EISSN2211-3843
出版年2012
卷号2期号:5页码:472-480
英文摘要

A rapid and sensitive LC MS/MS method for the simultaneous quantitation of lamivudine, zidovudine and nevirapine in human plasma using abacavir as internal standard has been developed and validated. The analytes and IS were extracted from plasma by solid phase extraction using Oasis HLB cartridges and separated on a Hypurity Advance C18 column using a mixture of acetonitrile:0.10/. formic acid (76:24, v/v) at a flow rate of 0.8 mL/min. Detection involved an API4000 LC MS/MS with electrospray ionization in the positive ion mode and multiplereaction monitoring for analysis. The method was validated according to FDA guidelines and shown to provide intra- and interday precision and accuracy within acceptable limits in a run time of only 3.5 min. The method was successfully applied to a pharmacokinetic study involving a single oral administration of a combination tablet to human male volunteers. (C) 2012 Institute of Materia Medica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association. Production and hosting by Elsevier B.V. All rights reserved.


英文关键词Lamivudine Zidovudine Nevirapine Solid phase extraction LC MS/MS Pharmacokinetics
类型Article
语种英语
国家India
收录类别SCI-E
WOS记录号WOS:000413439600006
WOS类目Pharmacology & Pharmacy
WOS研究方向Pharmacology & Pharmacy
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/170939
作者单位1.Jawaharlal Nehru Technol Univ, Coll Pharmaceut Sci, Hyderabad 500085, Andhra Pradesh, India;
2.Sri Venkateswara Univ, Dept Chem, Analyt & Environm Chem Div, Tirupati 517502, Andhra Pradesh, India;
3.Andhra Univ, Coll Pharmaceut Sci, Visakhapatnam 530003, Andhra Pradesh, India
推荐引用方式
GB/T 7714
Matta, Murali Krishna,Pilli, Nageswara Rao,Inamadugu, Jaswanth Kumar,et al. Simultaneous quantitation of lamivudine, zidovudine and nevirapine in human plasma by liquid chromatography-tandem mass spectrometry and application to a pharmacokinetic study[J],2012,2(5):472-480.
APA Matta, Murali Krishna,Pilli, Nageswara Rao,Inamadugu, Jaswanth Kumar,Burugula, Laxminarayana,&Rao, Seshagiri J. V. L. N..(2012).Simultaneous quantitation of lamivudine, zidovudine and nevirapine in human plasma by liquid chromatography-tandem mass spectrometry and application to a pharmacokinetic study.ACTA PHARMACEUTICA SINICA B,2(5),472-480.
MLA Matta, Murali Krishna,et al."Simultaneous quantitation of lamivudine, zidovudine and nevirapine in human plasma by liquid chromatography-tandem mass spectrometry and application to a pharmacokinetic study".ACTA PHARMACEUTICA SINICA B 2.5(2012):472-480.
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