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Continuing our investigations on medicinal plants of the Egyptian desert, two new triterpene glycoside derivatives, along with three known compounds have been isolated from the roots of Salsola imbricata, a shrub widely growing in Egypt. Their structures have been established as 3-O-beta-D-xylopyranosyl(1 -> 2)-O-beta-D-glucuronopyranosyl-akebonic acid 28-O-beta-D-glucopyranoside and 3-O-beta-D-xylopyranosyl-(1 -> 2)-O-beta-D-glucuronopyranosyl-29-hydroxyoleanolic acid 28-O-beta-D-glucopyranoside on the basis of spectroscopic methods including 1D-(H-1, C-13) and 2D-NMR (DQF-COSY, HSQC, HMBC) experiments as well as mass spectrometry analysis. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.