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An ethnobotanical exploration was carried out in Dir Kohistan Valleys. The checklist consisted of 65 species out of which 62 species were of 47 angiospermic families while three were of gymnospermic families. These plants were used medicinally and for other purposes. The investigation indicated that medicinal plants were used singly or in mixtures by local inhabitants. It was observed that unplanned exploitation had resulted in loss of medicinally important plant species. It was concluded that reforestation programs followed by proper protection is need of time.