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Eleven wheat genotypes in Micro-plot Wheat Yield Trial including two checks (AZRI-96 and local) were evaluated for drought, yield and disease resistance in order to incorporate the high yielding and disease resistant genotypes in our wheat breeding program. The experiment was conducted at Arid Zone Research Centre, Quetta under rainfed conditions during 2006-07. Micro-plot genotypes No. 1, 8 and 7 performed tremendously well as compared with the local checks. They produced significantly higher yield of 1345, 1307 and 1246 kg/ha with good drought resistance and higher resistance to stripe rust while the local check produced grain yield 1119 kg/ha and susceptible to yellow rust.